Discovery of imidazopyridine and imidazopyridazine inhibitors of PI3K

被引:0
|
作者
Han, Wooseok [1 ]
Pecchi, Sabina [1 ]
Burger, Matthew [1 ]
Lan, Jiong [1 ]
Smith, Aaron [1 ]
Knapp, Mark [1 ]
Huh, Kay [1 ]
De Menezes, Daniel Lopes [1 ]
Jansen, Johanna [1 ]
Merritt, Hanne [1 ]
Kaufman, Susan [1 ]
Voliva, Charles [1 ]
机构
[1] Novartis Inst Biomed Res, Emeryville, CA 94608 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
42-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Imidazopyridazine Inhibitors of PI3Kβ
    Rosse, Gerard
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (12): : 1012 - 1013
  • [2] Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
    Peterson, Emily A.
    Boezio, Alessandro A.
    Andrews, Paul S.
    Boezio, Christiane M.
    Bush, Tammy L.
    Cheng, Alan C.
    Choquette, Deborah
    Coats, James R.
    Colletti, Adria E.
    Copeland, Katrina W.
    DuPont, Michelle
    Graceffa, Russell
    Grubinska, Barbara
    Kim, Joseph L.
    Lewis, Richard T.
    Liu, Jingzhou
    Mullady, Erin L.
    Potashman, Michele H.
    Romero, Karina
    Shaffer, Paul L.
    Stanton, Mary K.
    Stellwagen, John C.
    Teffera, Yohannes
    Yi, Shuyan
    Cai, Ti
    La, Daniel S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (15) : 4967 - 4974
  • [3] Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K
    Pecchi, Sabina
    Ni, Zhi-Jie
    Han, Wooseok
    Smith, Aaron
    Lan, Jiong
    Burger, Matthew
    Merritt, Hanne
    Wiesmann, Marion
    Chan, John
    Kaufman, Susan
    Knapp, Mark S.
    Janssen, Johanna
    Huh, Kay
    Voliva, Charles F.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (16) : 4652 - 4656
  • [4] Discovery of Potent and Selective PI3Kγ Inhibitors
    Drew, Samuel L.
    Thomas-Tran, Rhiannon
    Beatty, Joel W.
    Fournier, Jeremy
    Lawson, Kenneth, V
    Miles, Dillon H.
    Mata, Guillaume
    Sharif, Ehesan U.
    Yan, Xuelei
    Mailyan, Artur K.
    Ginn, Elaine
    Chen, Jie
    Wong, Kent
    Soni, Divyank
    Dhanota, Puja
    Chen, Pei-Yu
    Shaqfeh, Stefan G.
    Meleza, Cesar
    Pham, Amber T.
    Chen, Ada
    Zhao, Xiaoning
    Banuelos, Jesus
    Jin, Lixia
    Schindler, Ulrike
    Walters, Matthew J.
    Young, Stephen W.
    Walker, Nigel P.
    Leleti, Manmohan Reddy
    Powers, Jay P.
    Jeffrey, Jenna L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (19) : 11235 - 11257
  • [5] Discovery and optimization of pyrimidone PI3Kβ inhibitors
    Halley, Frank
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [6] Structure guided optimization of a fragment hit to a series of imidazopyridine inhibitors of PI3K
    Pecchi, Sabina
    Han, Wooseok
    Ni, Zhi-Jie
    Burger, Matthew
    Smith, Aaron
    Knapp, Mark
    Jansen, Johanna
    Merritt, Hanne
    Kaufman, Susan
    Voliva, Charles
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [7] Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors
    Ma, Chen-Chen
    Zhang, Cheng-Mei
    Tang, Long-Qian
    Liu, Zhao-Peng
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 151 : 9 - 17
  • [8] Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors
    Jia, Hong
    Dai, Guangxiu
    Su, Weiguo
    Xiao, Kun
    Weng, Jianyang
    Zhang, Zhulin
    Wang, Qing
    Yuan, Tianhai
    Shi, Fuying
    Zhang, Zheng
    Chen, Wei
    Sai, Yang
    Wang, Jian
    Li, Xiong
    Cai, Yu
    Yu, Jun
    Ren, Ping
    Venable, Jennifer
    Rao, Tadimeti
    Edwards, James P.
    Bembenek, Scott D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (10) : 4936 - 4948
  • [9] Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors
    de Turiso, Felix Gonzalez-Lopez
    Shin, Youngsook
    Brown, Matthew
    Cardozo, Mario
    Chen, Yi
    Fong, David
    Hao, Xiaolin
    He, Xiao
    Henne, Kirk
    Hu, Yi-Ling
    Johnson, Michael G.
    Kohn, Todd
    Lohman, Julia
    McBride, Helen J.
    McGee, Lawrence R.
    Medina, Julio C.
    Metz, Daniela
    Miner, Kent
    Mohn, Deanna
    Pattaropong, Vatee
    Seganish, Jennifer
    Simard, Jillian L.
    Wannberg, Sharon
    Whittington, Douglas A.
    Yu, Gang
    Cushing, Timothy D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (17) : 7667 - 7685
  • [10] Discovery of novel class of alpha selective PI3K inhibitors
    Garland, Keira
    Hanan, Emily
    Staben, Steven
    Braun, Marie-Gabrielle
    Edgar, Kyle
    Endres, Nick
    Friedman, Lori
    Nguyen, Amanda
    Pang, Jodie
    Purkey, Hans
    Salphati, Laurent
    Schmidt, Stephen
    Song, Kyung
    Ultsch, Mark
    Jaochico, Allan
    Chan, Connie
    Eigenbrot, Charles
    MacLeod, Calum
    Jackson, Philip
    Narukulla, Raman
    Knight, Jamie
    Yeap, Kuen
    Messick, Kristen
    Valle, Nicole
    Heald, Robert
    Nannini, Michelle
    Hamilton, Pat
    Clausen, Saundra
    Young, Amy
    Sampath, Deepak
    Hong, Rebecca
    Lee, Man-Ling
    Blench, Toby
    Elliott, Richard
    Lu, Aijun
    Gu, Xiao-Hu
    Xin, Jianfeng
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254