pH-Responsive Hyperbranched Copolymers from One-Pot RAFT Copolymerization

被引：11

作者：

Tai, Hongyun ^{[1
]}

Duvall, Craig L. ^{[2
]}

Hoffman, Alan S. ^{[3
]}

Stayton, Patrick S. ^{[3
]}

Wang, Wenxin ^{[4
]}

机构：

[1] Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales

[2] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA

[3] Univ Washington, Dept Bioengn, Seattle, WA 98105 USA

[4] Natl Univ Ireland, Network Excellence Funct Biomat NFB, Galway, Ireland

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2012年 / 297卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

hyperbranched polymers; intracellular drug delivery; membrane-destabilizing materials; pH-responsive; RAFT polymerization; BRANCHED POLY(METHYL METHACRYLATE)S; BIOLOGICAL APPLICATIONS; RADICAL COPOLYMERIZATION; INTRACELLULAR DELIVERY; DENDRITIC POLYMERS; SMART POLYMERS; DRUG-DELIVERY; POLYMERIZATION; DENDRIMERS; DESIGN;

D O I：

10.1002/mame.201200227

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The synthesis of new pH-responsive hyperbranched copolymers via one pot RAFT copolymerization of PAA and a branching co-monomer PEGDA ((M) over bar (n)=258 Da) is reported. Three copolymers are prepared at monomer feed molar ratios [PAA](0)/[PEGDA](0)=99/1, 90/10, and 80/20. The resultant poly(PAA-PEGDA) copolymers are characterized by H-1 NMR, GPC, and DLS. These hyperbranched copolymers demonstrate composition-and size-dependent membrane disruptive properties by red blood cell hemolysis assay.

引用

页码：1175 / 1183

页数：9

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