pH-Responsive Hyperbranched Copolymers from One-Pot RAFT Copolymerization

被引：11
|
作者：
Tai, Hongyun [1 ]
Duvall, Craig L. [2 ]
Hoffman, Alan S. [3 ]
Stayton, Patrick S. [3 ]
Wang, Wenxin [4 ]
机构：
[1] Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales
[2] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
[3] Univ Washington, Dept Bioengn, Seattle, WA 98105 USA
[4] Natl Univ Ireland, Network Excellence Funct Biomat NFB, Galway, Ireland
来源：
MACROMOLECULAR MATERIALS AND ENGINEERING | 2012年 / 297卷 / 12期
基金：
英国工程与自然科学研究理事会;
关键词：
hyperbranched polymers; intracellular drug delivery; membrane-destabilizing materials; pH-responsive; RAFT polymerization; BRANCHED POLY(METHYL METHACRYLATE)S; BIOLOGICAL APPLICATIONS; RADICAL COPOLYMERIZATION; INTRACELLULAR DELIVERY; DENDRITIC POLYMERS; SMART POLYMERS; DRUG-DELIVERY; POLYMERIZATION; DENDRIMERS; DESIGN;
D O I：
10.1002/mame.201200227
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The synthesis of new pH-responsive hyperbranched copolymers via one pot RAFT copolymerization of PAA and a branching co-monomer PEGDA ((M) over bar (n)=258 Da) is reported. Three copolymers are prepared at monomer feed molar ratios [PAA](0)/[PEGDA](0)=99/1, 90/10, and 80/20. The resultant poly(PAA-PEGDA) copolymers are characterized by H-1 NMR, GPC, and DLS. These hyperbranched copolymers demonstrate composition-and size-dependent membrane disruptive properties by red blood cell hemolysis assay.
引用
收藏
页码：1175 / 1183
页数：9
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