Results of a placebo-controlled double blind randomised trial to investigate the efficacy of rifaximin-alpha versus placebo in improving systemic inflammation in patients with cirrhosis and chronic hepatic encephalopathy (RIFSYS Trial)

被引:1
|
作者
Patel, V. [1 ]
Mcphail, M. J. W. [1 ]
Zamalloa, A. [1 ]
Stoy, S. [1 ,2 ]
Vijay, G. M. [1 ]
Huang, X. [1 ]
Rogers, G. [3 ]
Choo, J. [3 ]
Edwards, L. [1 ]
Gray, E. [1 ]
Woodhouse, C. [1 ]
Gencer, S. [4 ]
Coen, M. [4 ]
Wendon, J. [1 ]
Bruce, K. [5 ]
Shawcross, D. [1 ]
机构
[1] Kings Coll London, Fac Life Sci & Med, Sch Immunol & Microbial Sci, James Black Ctr,Liver Sci, 1st Floor, London, England
[2] Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark
[3] South Australian Hlth & Med Res Inst, Microbiome Res, Adelaide, SA, Australia
[4] Imperial Coll London, Dept Surg & Canc, Div Computat & Syst Med, Biomol Med, London, England
[5] Kings Coll London, Inst Pharmaceut Sci, 5th Floor Franklin Wilkins Bldg, London, England
关键词
D O I
10.1016/S0168-8278(18)30432-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
LBP-005
引用
收藏
页码:S107 / S108
页数:2
相关论文
共 50 条
  • [21] Prevention of hepatic encephalopathy by administration of rifaximin and lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt (TIPS): a multicentre randomised, double blind, placebo controlled trial (PEARL trial)
    de Wit, K.
    Schaapman, J. J.
    Nevens, F.
    Verbeek, J.
    Coenen, S.
    Cuperus, F. J. C.
    Kramer, M.
    Tjwa, E. T. T. L.
    Mostafavi, N.
    Dijkgraaf, M. G. W.
    van Delden, O. M.
    Beuers, U. H. W.
    Coenraad, M. J.
    Takkenberg, R. B.
    BMJ OPEN GASTROENTEROLOGY, 2020, 7 (01):
  • [22] Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial
    Ryan, Nicole M.
    Birring, Surinder S.
    Gibson, Peter G.
    LANCET, 2012, 380 (9853): : 1583 - 1589
  • [23] Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial
    Gournay, V
    Roze, JC
    Kuster, A
    Daoud, P
    Cambonie, G
    Hascoet, JM
    Chamboux, C
    Blanc, T
    Fichtner, C
    Savagner, C
    Gouyon, JB
    Flurin, V
    Thiriez, G
    LANCET, 2004, 364 (9449): : 1939 - 1944
  • [24] Safety and efficacy of metformin in systemic lupus erythematosus: a multicentre, randomised, double-blind, placebo-controlled trial
    Sun, Fangfang
    Wang, Hui Jing
    Liu, Zhe
    Geng, Shikai
    Wang, Haiting
    Wang, Xiaodong
    Li, Ting
    Morel, Laurence
    Wan, Weiguo
    Lu, Liangjing
    Teng, Xiangyu
    Ye, Shuang
    LANCET RHEUMATOLOGY, 2020, 2 (04): : E210 - E216
  • [25] Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
    Szakacs, Zoltan
    Dauvilliers, Yves
    Mikhaylov, Vladimir
    Poverennova, Irina
    Krylov, Sergei
    Jankovic, Slavko
    Sonka, Karel
    Lehert, Philippe
    Lecomte, Isabelle
    Lecomte, Jeanne-Marie
    Schwartz, Jean-Charles
    LANCET NEUROLOGY, 2017, 16 (03): : 200 - 207
  • [26] The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial
    de Jonghe, Annemarieke
    van Munster, Barbara C.
    van Oosten, Hannah E.
    Goslings, J. Carel
    Kloen, Peter
    van Rees, Carolien
    Wolvius, Reinder
    van Velde, Romuald
    Levi, Marcel M.
    Korevaar, Joke C.
    de Rooij, Sophia E.
    BMC GERIATRICS, 2011, 11
  • [27] The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial
    Annemarieke de Jonghe
    Barbara C van Munster
    Hannah E van Oosten
    J Carel Goslings
    Peter Kloen
    Carolien van Rees
    Reinder Wolvius
    Romuald van Velde
    Marcel M Levi
    Joke C Korevaar
    Sophia E de Rooij
    BMC Geriatrics, 11
  • [28] DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF PHOSPHATIDYLSERINE IN ELDERLY PATIENTS WITH ARTERIOSCLEROTIC ENCEPHALOPATHY
    RANSMAYR, G
    PLORER, S
    GERSTENBRAND, F
    BAUER, G
    CLINICAL TRIALS JOURNAL, 1987, 24 (01) : 62 - 72
  • [29] Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial
    Khanna, Dinesh
    Lin, Celia J. F.
    Furst, Daniel E.
    Goldin, Jonathan
    Kim, Grace
    Kuwana, Masataka
    Allanore, Yannick
    Matucci-Cerinic, Marco
    Distler, Oliver
    Shima, Yoshihito
    van Laar, Jacob M.
    Spotswood, Helen
    Wagner, Bridget
    Siegel, Jeffrey
    Jahreis, Angelika
    Denton, Christopher P.
    LANCET RESPIRATORY MEDICINE, 2020, 8 (10): : 963 - 974
  • [30] A Critical Flicker Frequency Value of 32 Hz Predicts Recurrence of Overt Hepatic Encephalopathy in a Double-Blind, Placebo Controlled Trial of Rifaximin in Patients with Cirrhosis
    Butterworth, Roger F.
    Golden, Pamela L.
    Bortey, Enoch
    Paterson, Craig
    Forbes, William P.
    HEPATOLOGY, 2012, 56 : 916A - 917A