The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases

被引：29
|
作者：
Kiran, Tugce [1 ]
Demirkesen, Cuyan [1 ]
Eker, Candan [2 ]
Kumusoglu, Hakki [2 ]
Tuzuner, Nukhet [1 ]
机构：
[1] Istanbul Univ, Dept Pathol, Cerrahpasa Med Fac, TR-34098 Istanbul, Turkey
[2] Medimiks Med Biotechnol, Res & Dev Lab, Istanbul, Turkey
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 04期
关键词：
IRF4; translocation; MUM1; Cutaneous lymphomas; CD30; ALCL; MUM1; LYMPHOMAS;
D O I：
10.1016/j.leukres.2012.12.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(-) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：396 / 400
页数：5
相关论文
共 50 条
  • [41] The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma
    Boddicker, Rebecca L.
    Kip, N. Sertac
    Xing, Xiaoming
    Zeng, Yu
    Yang, Zhi-Zhang
    Lee, Jeong-Heon
    Almada, Luciana L.
    Elsawa, Sherine F.
    Knudson, Ryan A.
    Law, Mark E.
    Ketterling, Rhett P.
    Cunningham, Julie M.
    Wu, Yanhong
    Maurer, Matthew J.
    O'Byrne, Megan M.
    Cerhan, James R.
    Slager, Susan L.
    Link, Brian K.
    Porcher, Julie C.
    Grote, Deanna M.
    Jelinek, Diane F.
    Dogan, Ahmet
    Ansell, Stephen M.
    Fernandez-Zapico, Martin E.
    Feldman, Andrew L.
    BLOOD, 2015, 125 (20) : 3118 - 3127
  • [42] Expression of MUM1/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis
    Carbone, A
    Gloghini, A
    Cozzi, MR
    Capello, D
    Steffan, A
    Monini, P
    De Marco, L
    Gaidano, G
    BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (01) : 247 - 257
  • [43] IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
    Grusdat, M.
    McIlwain, D. R.
    Xu, H. C.
    Pozdeev, V. I.
    Knievel, J.
    Crome, S. Q.
    Robert-Tissot, C.
    Dress, R. J.
    Pandyra, A. A.
    Speiser, D. E.
    Lang, E.
    Maney, S. K.
    Elford, A. R.
    Hamilton, S. R.
    Scheu, S.
    Pfeffer, K.
    Bode, J.
    Mittruecker, H-W
    Lohoff, M.
    Huber, M.
    Haeussinger, D.
    Ohashi, P. S.
    Mak, T. W.
    Lang, K. S.
    Lang, P. A.
    CELL DEATH AND DIFFERENTIATION, 2014, 21 (07): : 1050 - 1060
  • [44] MUM1/IRF4 expression is an unfavorable prognostic factor in B-Cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Ito, M
    Iida, S
    Inagaki, H
    Tsuboi, K
    Komatsu, H
    Yamaguchi, M
    Nakamura, N
    Suzuki, R
    Seto, M
    Nakamura, S
    Morishima, Y
    Ueda, R
    JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (06): : 685 - 694
  • [45] IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
    M Grusdat
    D R McIlwain
    H C Xu
    V I Pozdeev
    J Knievel
    S Q Crome
    C Robert-Tissot
    R J Dress
    A A Pandyra
    D E Speiser
    E Lang
    S K Maney
    A R Elford
    S R Hamilton
    S Scheu
    K Pfeffer
    J Bode
    H-W Mittrücker
    M Lohoff
    M Huber
    D Häussinger
    P S Ohashi
    T W Mak
    K S Lang
    P A Lang
    Cell Death & Differentiation, 2014, 21 : 1050 - 1060
  • [46] IRF4 regulates IL-10 gene expression in CD4+ T cells through differential nuclear translocation
    Lee, Choong-Gu
    Hwang, Won
    Maeng, Ki-Eun
    Kwon, Ho-Keun
    So, Jae-Seon
    Sahoo, Anupama
    Lee, Sung Haeng
    Park, Zee Yong
    Im, Sin-Hyeog
    CELLULAR IMMUNOLOGY, 2011, 268 (02) : 97 - 104
  • [47] 外周T细胞淋巴瘤MUM1/IRF4蛋白的表达及其临床意义
    孙妍
    张清媛
    张明辉
    赵曙
    付晶
    李生兰
    临床肿瘤学杂志, 2012, 17 (03) : 215 - 218
  • [48] Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferongamma (MIG) gene expression in B-cell malignancy
    Iida, S
    Uranishi, M
    Sanda, T
    Ishida, T
    Tajima, E
    Ito, M
    Komatsu, H
    Inagaki, H
    Ueda, R
    BLOOD, 2004, 104 (11) : 315A - 315A
  • [49] Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements
    Frauenfeld, Leonie
    Castrejon-de-Anta, Natalia
    Enric Ramis-Zaldivar, Joan
    Streich, Sebastian
    Salmeron-Villalobos, Julia
    Otto, Franziska
    Mayer, Annika Katharina
    Steinhilber, Julia
    Pinyol, Magda
    Mankel, Barbara
    Ramsower, Colleen
    Bonzheim, Irina
    Fend, Falko
    Rimsza, Lisa M.
    Salaverria, Itziar
    Campo, Elias
    Balague, Olga
    Quintanilla-Martinez, Leticia
    BLOOD ADVANCES, 2022, 6 (07) : 2361 - 2372
  • [50] A clinicopathological study of B-cell differentiation markers and transcription factors in classical Hodgkin's lymphoma: a potential prognostic role of MUM1/IRF4
    Valsami, Serena
    Pappa, Vassiliki
    Rontogianni, Dimitra
    Kontsioti, Frieda
    Papageorgiou, Efstathios
    Dervenoulas, John
    Karmiris, Themis
    Papageorgiou, Sotirios
    Harhalakis, Nikolaos
    Xiros, Nikolaos
    Nikiforakis, Emmanuel
    Economopoulos, Theofanis
    HAEMATOLOGICA, 2007, 92 (10) : 1343 - 1350
12345