外周T细胞淋巴瘤MUM1/IRF4蛋白的表达及其临床意义

被引：4
|
作者：
孙妍
张清媛
张明辉
赵曙
付晶
李生兰
机构：
[1] 哈尔滨医科大学附属肿瘤医院内三科
来源：
临床肿瘤学杂志 | 2012年 / 17卷 / 03期
关键词：
T细胞淋巴瘤; MUM1/IRF4蛋白; 免疫组化; 预后;
D O I：
暂无
中图分类号：
R733.1 [网状内皮系统肿瘤];
学科分类号：
摘要：
目的研究MUM1/IRF4蛋白在外周T细胞淋巴瘤(PTCL)中的表达及临床意义。方法应用免疫组织化学SP法检测46例初治、诊断及分型明确的PTCL患者组织标本中MUM1/IRF4的表达,分析其表达与患者的临床病理特征、近期疗效及生存的关系。结果 46例PTCL患者的MUM1/IRF4阳性表达率为78.2%。MUM1/IRF4阴性表达者的有效率为80.0%,高于阳性者的46.7%(P<0.05)。全组患者的中位生存期为31.9个月(95%CI:26～34个月),MUM1/IRF4阴性表达者为28.0个月,阳性表达者为15.0个月,差异有统计学意义(P=0.026)。MUM1/IRF4阴性表达者的中位无进展生存期为19.0个月,阳性表达者为11.7个月,差异有统计学意义(P=0.041)。结论 MUM1/IRF4蛋白在PTCL中过表达提示预后不良,可作为判断PTCL预后的指标之一。
引用
收藏
页码：215 / 218
页数：4
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