Lost in space: design of experiments and scientific exploration in a Hogarth Universe

被引:22
|
作者
Lendrem, Dennis W. [1 ]
Lendrem, B. Clare [1 ]
Woods, David [2 ]
Rowland-Jones, Ruth [3 ]
Burke, Matthew [4 ]
Chatfield, Marion [5 ]
Isaacs, John D. [1 ]
Owen, Martin R. [5 ]
机构
[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
[2] Univ Southampton, Southampton Stat Sci Res Inst, Southampton, Hants, England
[3] Newcastle Univ, Ctr Bioengn, Newcastle Upon Tyne, Tyne & Wear, England
[4] GlaxoSmithKline, King Of Prussia, PA USA
[5] GlaxoSmithKline, Med Res Ctr, Stevenage, Herts, England
基金
英国工程与自然科学研究理事会;
关键词
HINDSIGHT BIAS; ENVIRONMENT; DISCOVERY; INFERENCE; OPTIMISM; SUCCESS; DOE;
D O I
10.1016/j.drudis.2015.09.015
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A Hogarth, or 'wicked', universe is an irregular environment generating data to support erroneous beliefs. Here, we argue that development scientists often work in such a universe. We demonstrate that exploring these multidimensional spaces using small experiments guided by scientific intuition alone, gives rise to an illusion of validity and a misplaced confidence in that scientific intuition. By contrast, design of experiments (DOE) permits the efficient mapping of such complex, multidimensional spaces. We describe simulation tools that enable research scientists to explore these spaces in relative safety.
引用
收藏
页码:1365 / 1371
页数:7
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