Novel bioactive parathyroid hormone and related peptides in teleost fish

被引：32
|
作者：
Canario, AVM
Rotllant, J
Fuentes, J
Guerreiro, PM
Teodósio, HR
Power, DM
Clark, MS
机构：
[1] Univ Algarve, Ctr Ciencias Mar Algarve, P-8005139 Faro, Portugal
[2] Univ Maryland, Inst Biotechnol, Ctr Marine Biotechnol, Dev Biol Lab, Baltimore, MD 21202 USA
[3] MRC, Rosalind Franklin Ctr Genom Res, Cambridge CB10 1SB, England
来源：
FEBS LETTERS | 2006年 / 580卷 / 01期
基金：
英国医学研究理事会;
关键词：
parathyroid hormone; parathyroid hormone-related peptide; calciotropic; receptor; adenylate cyclase; phospholipase C;
D O I：
10.1016/j.febslet.2005.12.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodonfluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：291 / 299
页数：9
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