Novel bioactive parathyroid hormone and related peptides in teleost fish

被引：32
|
作者：
Canario, AVM
Rotllant, J
Fuentes, J
Guerreiro, PM
Teodósio, HR
Power, DM
Clark, MS
机构：
[1] Univ Algarve, Ctr Ciencias Mar Algarve, P-8005139 Faro, Portugal
[2] Univ Maryland, Inst Biotechnol, Ctr Marine Biotechnol, Dev Biol Lab, Baltimore, MD 21202 USA
[3] MRC, Rosalind Franklin Ctr Genom Res, Cambridge CB10 1SB, England
来源：
FEBS LETTERS | 2006年 / 580卷 / 01期
基金：
英国医学研究理事会;
关键词：
parathyroid hormone; parathyroid hormone-related peptide; calciotropic; receptor; adenylate cyclase; phospholipase C;
D O I：
10.1016/j.febslet.2005.12.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodonfluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：291 / 299
页数：9
相关论文
共 50 条
  • [31] Fish Hydrolysates: A Regulatory Perspective of Bioactive Peptides
    Gevaert, Bert
    Veryser, Lieselotte
    Verbeke, Frederick
    Wynendaele, Evelien
    De Spiegeleer, Bart
    PROTEIN AND PEPTIDE LETTERS, 2016, 23 (12): : 1052 - 1060
  • [32] Stimulation of cortisol release by the N terminus of teleost parathyroid hormone-related protein in interrenal cells in vitro
    Rotllant, J
    Guerreiro, PM
    Anjos, L
    Redruello, B
    Canario, AVM
    Power, DM
    ENDOCRINOLOGY, 2005, 146 (01) : 71 - 76
  • [33] The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands
    Tucci, J
    Russell, A
    Senior, PV
    Fernley, R
    Ferraro, T
    Beck, F
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1996, 17 (02) : 149 - 157
  • [34] Expression of parathyroid hormone-related protein and the parathyroid hormone parathyroid hormone-related protein receptor in rat thymic epithelial cells
    Funk, JL
    Jones, GV
    Botham, CA
    Morgan, G
    Wooding, P
    Kendall, MD
    JOURNAL OF ANATOMY, 1999, 194 : 255 - 264
  • [35] Cloning and expression of guanylin-like peptides in teleost fish
    Cramb, G
    Martinez, AS
    McWilliam, IS
    Wilson, GD
    TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, 2005, 1040 : 277 - 280
  • [36] Identification of a parathyroid hormone in the fish, fugu rubripes
    Danks, JA
    Ho, PWH
    Notini, AJ
    Katsis, F
    Hoffmann, P
    Kemp, BE
    Martin, TJ
    Zajac, JD
    BONE, 2003, 32 (05) : S131 - S131
  • [37] Evidence for widespread distribution of piscidin antimicrobial peptides in teleost fish
    Silphaduang, U.
    Colorni, A.
    Noga, E. J.
    DISEASES OF AQUATIC ORGANISMS, 2006, 72 (03) : 241 - 252
  • [38] Identification of a parathyroid hormone in the fish Fugu rubripes
    Danks, JA
    Ho, PMW
    Notini, AJ
    Katsis, F
    Hoffmann, P
    Kemp, BE
    Martin, TJ
    Zajac, JD
    JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (07) : 1326 - 1331
  • [39] Improved bioavailability of orally delivered peptides and polypeptides in teleost fish
    Breton, B
    Roelants, Y
    Ollevier, F
    Epler, P
    Mikolajczyk, T
    JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE, 1998, 14 (3-4): : 251 - 257
  • [40] Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs as Therapies for Osteoporosis
    Marilyn Augustine
    Mara J. Horwitz
    Current Osteoporosis Reports, 2013, 11 : 400 - 406
12345