Protein 90K stimulates the immune system in ovarian cancer

被引：0
|
作者：
Zeimet, AG
Marth, C
Fuchs, D
Herold, M
Widschwendter, M
Daxenbichler, G
Iacobelli, S
Dapunt, O
机构：
[1] UNIV INNSBRUCK, INST MED CHEM & BIOCHEM, A-6020 INNSBRUCK, AUSTRIA
[2] UNIV INNSBRUCK, INNERE MED KLIN, A-6020 INNSBRUCK, AUSTRIA
[3] UNIV G DANNUNZIO, CATTEDRA ONCOL MED, CHIETI, ITALY
来源：
GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU | 1996年 / 36卷 / 01期
关键词：
tumor immunology; protein; 90K; interferon; ovarian cancer;
D O I：
10.1159/000272613
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology: it may represent a critical link between tumor and immune system.
引用
收藏
页码：44 / 45
页数：2
相关论文
共 50 条
  • [41] Determination of 90K levels in semen: Possible role in intratesticular immunosurveillance
    Caroppo, E
    Iacovazzi, PA
    Correale, M
    Carone, D
    Vizziello, G
    D'Amato, G
    TWENTIETH NATIONAL CONGRESS OF THE ITALIAN SOCIETY FOR FERTILITY AND STERILITY AND REPRODUCTIVE MEDICINE, 2000, : 409 - 413
  • [42] 90K superconductivity of clean Pb1212 epitaxial films
    Komori, S.
    Kondo, A.
    Kindo, K.
    Kakeya, I.
    SUPERCONDUCTOR SCIENCE & TECHNOLOGY, 2016, 29 (08):
  • [43] Elevated Levels of Circulating Immunostimulatory 90K in Henoch–Schoenlein Purpura
    P. Pelliccia
    C. Natoli
    M. T. Petitti
    A. Verrotti
    F. Chiarelli
    S. Iacobelli
    Journal of Clinical Immunology, 1999, 19 : 143 - 147
  • [44] EFFECTS OF TYPE-I AND TYPE-II INTERFERONS ON 90K ANTIGEN EXPRESSION IN OVARIAN-CARCINOMA CELLS
    MARTH, C
    DREPS, A
    NATOLI, C
    ZEIMET, AG
    LANG, T
    WIDSCHWENDTER, M
    DAXENBICHLER, G
    ULLRICH, A
    IACOBELLI, S
    INTERNATIONAL JOURNAL OF CANCER, 1994, 59 (06) : 808 - 813
  • [45] THE IMMUNE SYSTEM AS A BIOMARKER IN OVARIAN CANCER DIAGNOSIS
    Coosemans, A.
    Baert, T.
    Busschaert, P.
    Verbist, G.
    Van Rompuy, A. S.
    Vergote, I.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 1428 - 1428
  • [46] Harnessing the immune system for ovarian cancer therapy
    Odunsi, Kunle
    Sabbatini, Paul
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 59 (01) : 62 - 74
  • [47] THERMAL-CONDUCTIVITY AND LORENTZ FUNCTION OF YTTERBIUM BETWEEN 90K AND 300K
    CHUAH, DGS
    RATNALINGAM, R
    PHYSICS LETTERS A, 1973, A 44 (03) : 175 - 177
  • [48] N-terminal portion of β-catenin is important in ISGylation of β-catenin by 90K glycoprotein in colorectal cancer cells
    Yoon, Somy
    Bae, Jeong A.
    Kim, Hangun
    Moon, Kyung-Sub
    Kim, Kyung Keun
    CANCER RESEARCH, 2014, 74 (19)
  • [49] 60K gelatinase in involuting rat mammary gland is produced as a 90K proenzyme
    Ambili, M
    Sudhakaran, PR
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 45 (02): : 389 - 399
  • [50] Elevated levels of circulating immunostimulatory 90K in Henoch-Schoenlein purpura
    Pelliccia, P
    Natoli, C
    Petitti, MT
    Verrotti, A
    Chiarelli, F
    Iacobelli, S
    JOURNAL OF CLINICAL IMMUNOLOGY, 1999, 19 (02) : 143 - 147
12345