Protein 90K stimulates the immune system in ovarian cancer

被引：0

作者：

Zeimet, AG

Marth, C

Fuchs, D

Herold, M

Widschwendter, M

Daxenbichler, G

Iacobelli, S

Dapunt, O

机构：

[1] UNIV INNSBRUCK, INST MED CHEM & BIOCHEM, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK, INNERE MED KLIN, A-6020 INNSBRUCK, AUSTRIA

[3] UNIV G DANNUNZIO, CATTEDRA ONCOL MED, CHIETI, ITALY

来源：

GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU | 1996年 / 36卷 / 01期

关键词：

tumor immunology; protein; 90K; interferon; ovarian cancer;

D O I：

10.1159/000272613

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology: it may represent a critical link between tumor and immune system.

引用

页码：44 / 45

页数：2

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