Protein 90K stimulates the immune system in ovarian cancer

被引：0
|
作者：
Zeimet, AG
Marth, C
Fuchs, D
Herold, M
Widschwendter, M
Daxenbichler, G
Iacobelli, S
Dapunt, O
机构：
[1] UNIV INNSBRUCK, INST MED CHEM & BIOCHEM, A-6020 INNSBRUCK, AUSTRIA
[2] UNIV INNSBRUCK, INNERE MED KLIN, A-6020 INNSBRUCK, AUSTRIA
[3] UNIV G DANNUNZIO, CATTEDRA ONCOL MED, CHIETI, ITALY
来源：
GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU | 1996年 / 36卷 / 01期
关键词：
tumor immunology; protein; 90K; interferon; ovarian cancer;
D O I：
10.1159/000272613
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology: it may represent a critical link between tumor and immune system.
引用
收藏
页码：44 / 45
页数：2
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