A convenient synthesis of N-linked diglycose derivatives based on one-pot tandem Staudinger/aza-Wittig/reduction and biological evaluation

被引：1
|
作者：
Zhang, Pingzhu [1 ]
Li, Yinbo [1 ]
Liu, Ming [1 ]
Wang, Yanfei [1 ]
Li, Cuicui [1 ]
Ma, Donglai [1 ]
Chen, Hua [1 ]
Wang, Kerang [1 ]
Li, Xiaoliu [1 ,2 ]
Zhang, Jinchao [1 ]
机构：
[1] Hebei Univ, Key Lab Chem Biol Hebei Prov, Sch Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
CARBOHYDRATE RESEARCH | 2013年 / 372卷
基金：
中国国家自然科学基金;
关键词：
N-linked diglycoses; Staudinger/aza-Wittig/reduction; One pot reaction; Glycosidase inhibition; Antitumor; MICROWAVE; DISACCHARIDES; ETHERS;
D O I：
10.1016/j.carres.2013.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel N-linked diglycose derivatives 9 and 10 were conveniently and directly synthesized based on the key step of one-pot tandem Staudinger/aza-Wittig/reduction reaction from the azido sugar and sugar-derived aldehyde followed by deprotection. The biological activities against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and HIV-RT and antitumor activity of these compounds were preliminarily evaluated. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：15 / 22
页数：8
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