A convenient synthesis of N-linked diglycose derivatives based on one-pot tandem Staudinger/aza-Wittig/reduction and biological evaluation

被引：1

作者：

Zhang, Pingzhu ^{[1
]}

Li, Yinbo ^{[1
]}

Liu, Ming ^{[1
]}

Wang, Yanfei ^{[1
]}

Li, Cuicui ^{[1
]}

Ma, Donglai ^{[1
]}

Chen, Hua ^{[1
]}

Wang, Kerang ^{[1
]}

Li, Xiaoliu ^{[1
,2
]}

Zhang, Jinchao ^{[1
]}

机构：

[1] Hebei Univ, Key Lab Chem Biol Hebei Prov, Sch Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2013年 / 372卷

基金：

中国国家自然科学基金;

关键词：

N-linked diglycoses; Staudinger/aza-Wittig/reduction; One pot reaction; Glycosidase inhibition; Antitumor; MICROWAVE; DISACCHARIDES; ETHERS;

D O I：

10.1016/j.carres.2013.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel N-linked diglycose derivatives 9 and 10 were conveniently and directly synthesized based on the key step of one-pot tandem Staudinger/aza-Wittig/reduction reaction from the azido sugar and sugar-derived aldehyde followed by deprotection. The biological activities against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and HIV-RT and antitumor activity of these compounds were preliminarily evaluated. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：15 / 22

页数：8

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