Current developments in the discovery and design of new drug candidates from plant natural product leads

被引：150

作者：

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 02期

关键词：

D O I：

10.1021/np030373o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.

引用

页码：273 / 283

页数：11

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