Current developments in the discovery and design of new drug candidates from plant natural product leads

被引：150
|
作者：
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 02期
关键词：
D O I：
10.1021/np030373o
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.
引用
收藏
页码：273 / 283
页数：11
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