Solvent-Free Microwave Assisted Synthesis of Novel Pyrazole-Oxopyrrolidine and Pyrazole-Oxopiperidine Derivatives and Their Antimicrobial Activity

被引：7
|
作者：
Jassem, A. M. [1 ]
Almashal, F. A. K. [1 ]
Jaber, H. A. S. [1 ]
机构：
[1] Basrah Univ, Coll Educ Pure Sci, Dept Chem, Basrah 61004, Iraq
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 05期
关键词：
solvent-free synthesis; microwave; antimicrobial activity; pyrazole-oxopyrrolidine derivatives; IN-VITRO;
D O I：
10.1134/S1070363220050230
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we report an efficient one-pot multicomponent synthesis of novel pyrazole-oxopyrrolidine derivatives via the Ugi (4C3C) reaction under MW solvent-free conditions. The structures of products have been characterized by FTIR,H-1 and(13)C NMR, and mass spectrometry, and HPLC analysis. All synthesized compounds have been tested for their antimicrobial activity and some of those characterized as highly active.
引用
收藏
页码：895 / 900
页数：6
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