Solving the genetic puzzle of systemic lupus erythematosus

被引：7

作者：

Yang, Wanling ^{[1
]}

Lau, Yu Lung ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Paediat & Adolescent Med, Pokfulam, Hong Kong, Peoples R China

来源：

PEDIATRIC NEPHROLOGY | 2015年 / 30卷 / 10期

关键词：

Systemic lupus erythematosus; Genetics; Susceptibility; Missing heritability; ACUTE LYMPHOBLASTIC-LEUKEMIA; GENOME-WIDE ASSOCIATION; HONG-KONG CHINESE; DRUG-INDUCED LUPUS; LOSS-OF-FUNCTION; SUSCEPTIBILITY VARIANTS; RHEUMATOID-ARTHRITIS; RISK LOCI; MISSING HERITABILITY; INHIBITOR P27(KIP1);

D O I：

10.1007/s00467-014-2947-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In recent years, genome-wide association studies on systemic lupus erythematosus (SLE) have significantly improved our understanding of the genetic architecture of this prototypic autoimmune disease. However, there is still a long way to go before we can fully understand the genetic factors for this very heterogeneous disease and the interplays between environmental factors and genetic predisposition that lead to the pathogenesis of SLE. Here we summarize the recent advances in our understanding of the genetics of SLE and discuss the future directions towards fully elucidating the mechanisms of this disease.

引用

页码：1735 / 1748

页数：14

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