Solving the genetic puzzle of systemic lupus erythematosus

被引：7

作者：

Yang, Wanling ^{[1
]}

Lau, Yu Lung ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Paediat & Adolescent Med, Pokfulam, Hong Kong, Peoples R China

来源：

PEDIATRIC NEPHROLOGY | 2015年 / 30卷 / 10期

关键词：

Systemic lupus erythematosus; Genetics; Susceptibility; Missing heritability; ACUTE LYMPHOBLASTIC-LEUKEMIA; GENOME-WIDE ASSOCIATION; HONG-KONG CHINESE; DRUG-INDUCED LUPUS; LOSS-OF-FUNCTION; SUSCEPTIBILITY VARIANTS; RHEUMATOID-ARTHRITIS; RISK LOCI; MISSING HERITABILITY; INHIBITOR P27(KIP1);

D O I：

10.1007/s00467-014-2947-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In recent years, genome-wide association studies on systemic lupus erythematosus (SLE) have significantly improved our understanding of the genetic architecture of this prototypic autoimmune disease. However, there is still a long way to go before we can fully understand the genetic factors for this very heterogeneous disease and the interplays between environmental factors and genetic predisposition that lead to the pathogenesis of SLE. Here we summarize the recent advances in our understanding of the genetics of SLE and discuss the future directions towards fully elucidating the mechanisms of this disease.

引用

页码：1735 / 1748

页数：14

共 50 条

[31] Exploring the etiopathogenesis of systemic lupus erythematosus: a genetic perspective
Ali Javinani
Amir Ashraf-Ganjouei
Saeed Aslani
Ahmadreza Jamshidi
Mahdi Mahmoudi
Immunogenetics, 2019, 71 : 283 - 297
[32] Genetic Determinants of Childhood Onset Systemic Lupus Erythematosus
Nelson, Meghan
Murthy, Shanta
Maddipatla, Sushma
Shenoy, Sreekala
Ponder, Lori
Kugathasan, Subra
Cutler, Dave
Prahalad, Sampath
ARTHRITIS & RHEUMATOLOGY, 2024, 76 : 1292 - 1294
[33] GENETIC AND IMMUNE ASPECTS OF SYSTEMIC LUPUS-ERYTHEMATOSUS
TAUROG, JD
STEINBERG, AD
INTERNATIONAL JOURNAL OF DERMATOLOGY, 1981, 20 (03) : 149 - 158
[34] GENETIC ANALYSIS OF THE PENTRAXIN GENES IN SYSTEMIC LUPUS ERYTHEMATOSUS
Russell, A. I.
Walport, M. J.
Vyse, T. J.
RHEUMATOLOGY, 2002, 41 : 12 - 12
[35] Exploring the etiopathogenesis of systemic lupus erythematosus: a genetic perspective
Javinani, Ali
Ashraf-Ganjouei, Amir
Aslani, Saeed
Jamshidi, Ahmadreza
Mahmoudi, Mahdi
IMMUNOGENETICS, 2019, 71 (04) : 283 - 297
[36] An update on genetic studies of systemic lupus erythematosus.
Tsao B.P.
Current Rheumatology Reports, 2002, 4 (4) : 359 - 367
[37] Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld, Carl D.
Ainsworth, Hannah C.
Graham, Deborah S. Cunninghame
Kelly, Jennifer A.
Comeau, Mary E.
Marion, Miranda C.
Howard, Timothy D.
Ramos, Paula S.
Croker, Jennifer A.
Morris, David L.
Sandling, Johanna K.
Almlof, Jonas Carlsson
Acevedo-Vasquez, Eduardo M.
Alarcon, Graciela S.
Babini, Alejandra M.
Baca, Vicente
Bengtsson, Anders A.
Berbotto, Guillermo A.
Bijl, Marc
Brown, Elizabeth E.
Brunner, Hermine I.
Cardiel, Mario H.
Catoggio, Luis
Cervera, Ricard
Cucho-Venegas, Jorge M.
Dahlqvist, Solbritt Rantapaa
D'Alfonso, Sandra
Da Silva, Berta Martins
de la Rua Figueroa, Inigo
Doria, Andrea
Edberg, Jeffrey C.
Endreffy, Emoke
Esquivel-Valerio, Jorge A.
Fortin, Paul R.
Freedman, Barry I.
Frostegard, Johan
Garcia, Mercedes A.
Garcia de la Torre, Ignacio
Gilkeson, Gary S.
Gladman, Dafna D.
Gunnarsson, Iva
Guthridge, Joel M.
Huggins, Jennifer L.
James, Judith A.
Kallenberg, Cees G. M.
Kamen, Diane L.
Karp, David R.
Kaufman, Kenneth M.
Kottyan, Leah C.
Kovacs, Laszlo
NATURE COMMUNICATIONS, 2017, 8
[38] Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus
Ho, Roger C.
Ong, Huiyi
Thiaghu, Chandra
Lu, Yanxia
Ho, Cyrus S.
Zhang, Melvyn W.
JOURNAL OF RHEUMATOLOGY, 2016, 43 (03) : 541 - 551
[39] GENETIC-FACTORS IN SYSTEMIC LUPUS-ERYTHEMATOSUS
RUSSELL, AS
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1981, 10 (04) : 255 - 263
[40] GENETIC-ANALYSIS OF SYSTEMIC LUPUS-ERYTHEMATOSUS
OSTERMEYER, EA
NEWMAN, B
ROWELL, SE
BUSS, KA
NICKERSON, DA
HOOD, L
KING, MC
AMERICAN JOURNAL OF HUMAN GENETICS, 1993, 53 (03) : 205 - 205

← 1 2 3 4 5 →