A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

被引：106

作者：

Guo, Ting ^{[1
]}

Cui, Lei ^{[1
]}

Shen, Jiaoning ^{[1
]}

Wang, Rui ^{[1
]}

Zhu, Weiping ^{[1
]}

Xu, Yufang ^{[1
]}

Qian, Xuhong ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 18期

基金：

国家高技术研究发展计划(863计划);

关键词：

HYPOCHLOROUS-ACID; REACTIVE OXYGEN; NITRIC-OXIDE; MYELOPEROXIDASE; PEROXYNITRITE; SUPEROXIDE; BIOLOGY; STRESS; DESIGN;

D O I：

10.1039/c3cc38471c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO-). Upon addition of ClO-, significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO- led to only a single-channel fluorescence enhancement. This feature makes it a clear advantage in distinguishing ClO-, RNS from other ROS.

引用

页码：1862 / 1864

页数：3

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