High IL-18 (interferon-γ inducing factor) concentration in a purine nucleoside phosphorylase deficient patient

被引：8
|
作者：
Yamamoto, T
Moriwaki, Y
Matsui, K
Takahashi, S
Tsutsui, H
Yoshimoto, T
Okamura, H
Nakanishi, K
Kurosawa, Y
Yamaguchi, S
Sasaki, Y
Higashino, K
机构：
[1] Hyogo Coll Med, Dept Internal Med 3, Nishinomiya, Hyogo 6638501, Japan
[2] Hyogo Coll Med, Dept Immunol & Med Zool, Nishinomiya, Hyogo 6638501, Japan
[3] Hyogo Coll Med, Inst Adv Med Sci, Host Def Lab, Nishinomiya, Hyogo 6638501, Japan
[4] Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan
[5] Kitasato Inst Hosp, Dept Pediat, Tokyo, Japan
[6] Natl Inst Infect Dis, Dept Safety Res Biol, Tokyo, Japan
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 1999年 / 81卷 / 02期
关键词：
purine nucleoside phosphorylase deficiency; interferon-gamma inducing factor; cytokines;
D O I：
10.1136/adc.81.2.179
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.
引用
收藏
页码：179 / 180
页数：2
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