High IL-18 (interferon-γ inducing factor) concentration in a purine nucleoside phosphorylase deficient patient

被引：8

作者：

Yamamoto, T

Moriwaki, Y

Matsui, K

Takahashi, S

Tsutsui, H

Yoshimoto, T

Okamura, H

Nakanishi, K

Kurosawa, Y

Yamaguchi, S

Sasaki, Y

Higashino, K

机构：

[1] Hyogo Coll Med, Dept Internal Med 3, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Coll Med, Dept Immunol & Med Zool, Nishinomiya, Hyogo 6638501, Japan

[3] Hyogo Coll Med, Inst Adv Med Sci, Host Def Lab, Nishinomiya, Hyogo 6638501, Japan

[4] Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan

[5] Kitasato Inst Hosp, Dept Pediat, Tokyo, Japan

[6] Natl Inst Infect Dis, Dept Safety Res Biol, Tokyo, Japan

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1999年 / 81卷 / 02期

关键词：

purine nucleoside phosphorylase deficiency; interferon-gamma inducing factor; cytokines;

D O I：

10.1136/adc.81.2.179

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.

引用

页码：179 / 180

页数：2

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