Synthesis of some 2-imidoylimino-2,3-dihydro-thiazolo[4,5-d]pyrimidines

被引：0
|
作者：
Rensky, Mikhail A. [1 ]
Zyabrev, Vladimir S. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine
来源：
ARKIVOC | 2015年
关键词：
1,2,4-Thiadizol-5(2H)-imines; N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; thiazolo[4,5-d]pyrimidines; cycloaddition; substitution; cyclization; SUBSTITUTED 1,2,4-THIADIAZOL-5(2H)-IMINES; CYCLOADDITION; PRODUCTS; SERIES; AGENTS; DESIGN;
D O I：
10.3998/ark.5550190.p008.867
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The paper is concerned with chemistry of thiazolo[4,5-d]pyrimidine derivatives bearing a 1,3-diazapropenylidene fragment at position 2 and an oxygen or a mobile chlorine atom at position 7. These compounds are obtained in three steps: (i) cycloaddition of malononitrile to available 1,2,4-thiadiazol-5(2H)-imines to form N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; (ii) their acylation or condensation with DMF dimethyl acetal followed by; (iii) pyrimidine ring closure.
引用
收藏
页码：110 / 120
页数：11
相关论文
共 50 条
  • [41] Synthesis of 2,4-disubstituted pyrimido[4,5-d]indoles, pyrano[4',3':4,5]pyrrolo[2,3-d]pyrimidines and some reactions of pyrimido[4,5-b]indoles
    Paronikyan, EG
    Noravyan, AS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1996, (10): : 1413 - 1416
  • [42] Synthesis and structure of some 6,7-dihydro-thiazolo[4,5-d][1,3,2]diaza-λ5-phosphorines
    Rensky, MA
    Zyabrev, VS
    Chernega, AN
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2003, 178 (10) : 2127 - 2135
  • [43] Synthesis of thiazolo[4,5-d]pyrimidine derivatives as potential antimicrobial agents
    Habib, Nargues S.
    Solliman, Raafat
    El-Tombary, Alaa A.
    El-Hawash, Soad A.
    Shaaban, Omaima G.
    ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (12) : 1511 - 1520
  • [44] Identification of important structural features of thiazolo[4,5-d]pyrimidines required for potent antifungal activity
    Mahesh Chhabria
    Ishwarsinh Rathod
    Khushbu Vala
    Paulomi Patel
    Medicinal Chemistry Research, 2011, 20 : 1450 - 1454
  • [45] IDENTIFICATION OF IMPORTANT STRUCTURAL FEATURES OF THIAZOLO[4,5-D]PYRIMIDINES REQUIRED FOR POTENT ANTIFUNGAL ACTIVITY
    Chhabria, Mahesh
    Rathod, Ishwarsinh
    Vala, Khushbu
    Patel, Paulomi
    MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S98 - S99
  • [46] Identification of important structural features of thiazolo[4,5-d]pyrimidines required for potent antifungal activity
    Chhabria, Mahesh
    Rathod, Ishwarsinh
    Vala, Khushbu
    Patel, Paulomi
    MEDICINAL CHEMISTRY RESEARCH, 2011, 20 (09) : 1450 - 1454
  • [47] Synthesis of thiazolo[4,5-d]pyrimidine derivatives as potential antimicrobial agents
    Nargues S. Habib
    Raafat Soliman
    Alaa A. El-Tombary
    Soad A. El-Hawash
    Omaima G. Shaaban
    Archives of Pharmacal Research, 2007, 30
  • [48] Synthesis and biological evaluation of some novel urea and thiourea derivatives of isoxazolo[4,5-d]pyridazine and structurally related thiazolo[4,5-d]pyridazine as antimicrobial agents
    Faidallah, Hassan M.
    Rostom, Sherif A. F.
    Basaif, Salem A.
    Makki, Mohammed S. T.
    Khan, Khalid A.
    ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (11) : 1354 - 1368
  • [49] Synthesis and Cytotoxic Activity of Some Novel Thieno [2,3-d:4,5-d′] Dipyrimidine Derivatives
    El-Sayed, Elsherbiny Hamdy
    Fadda, Ahmed Ali
    ACTA CHIMICA SLOVENICA, 2018, 65 (04) : 853 - 864
  • [50] Synthesis and biological evaluation of some novel urea and thiourea derivatives of isoxazolo[4,5-d]pyridazine and structurally related thiazolo[4,5-d]pyridazine as antimicrobial agents
    Hassan M. Faidallah
    Sherif A. F. Rostom
    Salem A. Basaif
    Mohammed S. T. Makki
    Khalid A. Khan
    Archives of Pharmacal Research, 2013, 36 : 1354 - 1368
12345