Synthesis of some 2-imidoylimino-2,3-dihydro-thiazolo[4,5-d]pyrimidines

被引：0

作者：

Rensky, Mikhail A. ^{[1
]}

Zyabrev, Vladimir S. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine

来源：

ARKIVOC | 2015年

关键词：

1,2,4-Thiadizol-5(2H)-imines; N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; thiazolo[4,5-d]pyrimidines; cycloaddition; substitution; cyclization; SUBSTITUTED 1,2,4-THIADIAZOL-5(2H)-IMINES; CYCLOADDITION; PRODUCTS; SERIES; AGENTS; DESIGN;

D O I：

10.3998/ark.5550190.p008.867

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The paper is concerned with chemistry of thiazolo[4,5-d]pyrimidine derivatives bearing a 1,3-diazapropenylidene fragment at position 2 and an oxygen or a mobile chlorine atom at position 7. These compounds are obtained in three steps: (i) cycloaddition of malononitrile to available 1,2,4-thiadiazol-5(2H)-imines to form N-(4-amino-5-cyanothiazol-2(3H)-ylidene)amidines; (ii) their acylation or condensation with DMF dimethyl acetal followed by; (iii) pyrimidine ring closure.

引用

页码：110 / 120

页数：11

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