Acremonium kiliense: Case Report and Review of Published Studies

被引:16
|
作者
Camplesi Junior, Milton [1 ]
Arantes, Adriano de Moraes [2 ]
Silva, Hildene Meneses [3 ]
Costa, Carolina Rodrigues [3 ]
Rodrigues Silva, Maria do Rosario [3 ]
机构
[1] Univ Paulista UNIP Goias, Goiania, Go, Brazil
[2] Hosp Araujo Jorge, Assoc Combate Canc Estado Goias, Goiania, Go, Brazil
[3] Univ Fed Goias UFG, Inst Patol Trop & Saude Publ, BR-74605050 Goiania, Go, Brazil
关键词
Acremonium kiliense; Hematopoietic stem cell transplant; Voriconazole; FUNGAL-INFECTIONS; STRICTUM INFECTION; EPIDEMIOLOGY; PERITONITIS; FUNGEMIA;
D O I
10.1007/s11046-013-9700-x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Changes in the spectrum of clinically important fungal infection have been observed in recent years. Acremonium species has been responsible for eumycotic mycetomas but has also been increasingly implicated in systemic fungal diseases. A case of Acremonium kiliense fungemia with proven involvement of the lungs in an allogeneic hematopoietic stem cell patient is reported. A high-resolution computed tomography scan of the lungs showed nodules in both lungs. Multiple cultures of blood demonstrated narrow septate hyphae, cylindrical conidia, and solitary tapering phialides and microconidia that remained grouped in slimy heads. The isolate was identified as A. kiliense based on its morphological characteristics and DNA sequence analysis. Susceptibility testing of the clinical isolate was performed to four antifungal agents. Amphotericin B, fluconazole and itraconazole were found to be inactive in vitro against the isolate; however, it was found to be sensitive to voriconazole. This last drug was indicated, and a high-resolution computed tomography scan of the lungs was normal after 10 days. One year later, the patient was free of symptoms and her blood culture was negative for fungi. Thus, voriconazole was effective in treatment for life-threatening A. kiliense infections. In this work, we performed an overview of worldwide clinical infections caused by A. kiliense.
引用
收藏
页码:417 / 421
页数:5
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