Estimation of apoptosis in C6 glioma cells treated with antidepressants

被引：0
|
作者：
Spanova, A
Kovaru, H
Lisa, V
Lukasova, E
Rittich, B
机构：
[1] TECH UNIV,FAC CHEM,BRNO 63700,CZECH REPUBLIC
[2] ACAD SCI CZECH REPUBL,INST ANIM PHYSIOL & GENET,BRNO,CZECH REPUBLIC
[3] CHARLES UNIV,FAC MED 1,PRAGUE,CZECH REPUBLIC
[4] ACAD SCI CZECH REPUBL,INST PHYSIOL,PRAGUE,CZECH REPUBLIC
[5] ACAD SCI CZECH REPUBL,INST BIOPHYS,CS-61265 BRNO,CZECH REPUBLIC
来源：
PHYSIOLOGICAL RESEARCH | 1997年 / 46卷 / 02期
关键词：
glioma cells; antidepressants; DNA fragmentation; apoptosis; DNA FRAGMENTATION;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine). Some discrete bands containing a population of short DNA fragments appeared after 1 and 5 days of cultivation. Apoptotic DNA breaks were verified at single cell level using the TUNEL test in cells treated with fluoxetine.
引用
收藏
页码：161 / 164
页数：4
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