T cell specific loss of PTPN2 results in aggravated colitis and pronounced intestinal dysbiosis as observed in Crohn's disease patients

被引:0
|
作者
Spalinger, M. [1 ]
Chassard, C. [2 ]
Kasper, S. [1 ]
Biedermann, L. [1 ]
Vavricka, S. [3 ]
Frey-Wagner, I. [1 ]
Atrott, K. [1 ]
Lacroix, C. [2 ]
Fried, M. [1 ,4 ]
Rogler, G. [1 ,4 ]
Scharl, M. [1 ,4 ]
机构
[1] Univ Zurich Hosp, Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
[2] ETH, Inst Food Nutr & Hlth, Zurich, Switzerland
[3] Hosp Triemli, Gastroenterol & Hepatol, Zurich, Switzerland
[4] Univ Zurich, Zurich Inst Human Physiol, Zurich, Switzerland
来源
关键词
D O I
10.1016/S1873-9946(14)60142-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
P019
引用
收藏
页码:S72 / S72
页数:1
相关论文
共 50 条
  • [31] Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn's Disease Patients
    Chapuy, Laurence
    Sarfati, Marika
    CELLS, 2020, 9 (04)
  • [32] Pharmacokinetics, Safety and Efficacy of Intravenous Vedolizumab in Paediatric Patients with Ulcerative Colitis or Crohn's Disease: Results from the Phase 2 HUBBLE Study
    Hyams, Jeffrey S.
    Turner, Dan
    Cohen, Stanley A.
    Szakos, Erzsebet
    Kowalska-Duplaga, Kinga
    Ruemmele, Frank
    Croft, Nicholas M.
    Korczowski, Bartosz
    Lawrence, Promise
    Bhatia, Siddharth
    Kadali, Harisha
    Chen, Chunlin
    Sun, Wan
    Rosario, Maria
    Kabilan, Senthil
    Treem, William
    Rossiter, Guillermo
    Lirio, Richard A.
    JOURNAL OF CROHNS & COLITIS, 2022, 16 (08): : 1243 - 1254
  • [33] Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn's disease and ulcerative colitis patients
    Papa-Gobbi, Rodrigo
    Muglia, Cecilia I.
    Rocca, Andres
    Curciarello, Renata
    Sambuelli, Alicia M.
    Yantorno, Martin
    Correa, Gustavo
    Morosi, Luciano G.
    Di Sabatino, Antonio
    Biancheri, Paolo
    MacDonald, Thomas T.
    Toscano, Marta A.
    Marino, Karina V.
    Rabinovich, Gabriel A.
    Docena, Guillermo H.
    APOPTOSIS, 2021, 26 (5-6) : 323 - 337
  • [34] Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn’s disease and ulcerative colitis patients
    Rodrigo Papa-Gobbi
    Cecilia I. Muglia
    Andrés Rocca
    Renata Curciarello
    Alicia M. Sambuelli
    Martín Yantorno
    Gustavo Correa
    Luciano G. Morosi
    Antonio Di Sabatino
    Paolo Biancheri
    Thomas T. MacDonald
    Marta A. Toscano
    Karina V. Mariño
    Gabriel A. Rabinovich
    Guillermo H. Docena
    Apoptosis, 2021, 26 : 323 - 337
  • [35] Enhanced Cbirl specific induction of monocyte (IL-6) and T cell (proliferation and IFN-γ) responses in Crohn's disease patients
    Shen, Chong
    Landers, Carol
    Derkowski, Carrie
    Elson, Charles O.
    Targan, Stephan R.
    GASTROENTEROLOGY, 2007, 132 (04) : A63 - A63
  • [36] Analysing the T cell receptor beta chain repertoire of 2,800 Inflammatory Bowel Disease patients identifies public T cell responses involved in the pathogenesis of Crohn's Disease and Ulcerative Colitis and quantifies the impact of surgery and therapy on the immune repertoire of IBD patients
    Elabd, H.
    Mahdy, A.
    Franke, A.
    JOURNAL OF CROHNS & COLITIS, 2025, 19 : i21 - i23
  • [37] PHARMACOKINETICS (PK), SAFETY, AND EFFICACY OF INTRAVENOUS (IV) VEDOLIZUMAB IN PEDIATRIC PATIENTS WITH ULCERATIVE COLITIS OR CROHN'S DISEASE: RESULTS FROM THE PHASE 2 HUBBLE STUDY
    Hyams, Jeffrey S.
    Turner, Dan
    Cohen, Stanley A.
    Szakos, Erzsebet
    Kowalska-Duplaga, Kinga
    Ruemmele, Frank
    Croft, Nicholas M.
    Korczowski, Bartosz
    Lawrence, Promise
    Bhatia, Siddharth
    Kadali, Harisha
    Chen, Chunlin
    Sun, Wan
    Rosario, Maria
    Suri, Ajit
    Gulati, Parul
    Treem, William
    Rossiter, Guillermo
    Lirio, Richard A.
    GASTROENTEROLOGY, 2021, 160 (06) : S716 - S716
  • [38] IgG responses to multiple bacterial flagellins identify a subgroup of paediatric therapynaive Crohn's disease patients with increased microbiota-specific T-cell reactivity
    Costes, L.
    Tindemans, I.
    Joosse, M. E.
    Aardoom, M. A.
    Jongsma, M. M. E.
    Raatgeep, R. H. C.
    van Haaften, D. H.
    Alexander, K. L.
    Duck, L. W.
    Heikema, A. P.
    Kemos, P.
    Escher, J. C.
    Ruemmele, F. M.
    Croft, N. M.
    Elson, C. O.
    de Ridder, L.
    Samsom, J. N.
    JOURNAL OF CROHNS & COLITIS, 2020, 14 : S046 - S046
  • [39] Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets
    Venema, Werna T. Uniken
    Voskuil, Michiel D.
    Vila, Arnau Vich
    van der Vries, Gerben
    Jansen, Bernadien H.
    Jabri, Bana
    Faber, Klaas Nico
    Dijkstra, Gerard
    Xavier, Ramnik J.
    Wijmenga, Cisca
    Graham, Daniel B.
    Weersma, Rinse K.
    Festen, Eleonora A.
    GASTROENTEROLOGY, 2019, 156 (03) : 812 - +
  • [40] Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: Preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells
    Okumura, Shigeru
    Yuki, Keisuke
    Kobayashi, Ryota
    Okamura, Shinichi
    Ohmori, Kazumitsu
    Saito, Hirohisa
    Ra, Chisei
    Okayama, Yoshimichi
    CLINICAL IMMUNOLOGY, 2009, 130 (02) : 175 - 185