T cell specific loss of PTPN2 results in aggravated colitis and pronounced intestinal dysbiosis as observed in Crohn's disease patients

被引：0
|
作者：
Spalinger, M. [1 ]
Chassard, C. [2 ]
Kasper, S. [1 ]
Biedermann, L. [1 ]
Vavricka, S. [3 ]
Frey-Wagner, I. [1 ]
Atrott, K. [1 ]
Lacroix, C. [2 ]
Fried, M. [1 ,4 ]
Rogler, G. [1 ,4 ]
Scharl, M. [1 ,4 ]
机构：
[1] Univ Zurich Hosp, Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
[2] ETH, Inst Food Nutr & Hlth, Zurich, Switzerland
[3] Hosp Triemli, Gastroenterol & Hepatol, Zurich, Switzerland
[4] Univ Zurich, Zurich Inst Human Physiol, Zurich, Switzerland
来源：
JOURNAL OF CROHNS & COLITIS | 2014年 / 8卷
关键词：
D O I：
10.1016/S1873-9946(14)60142-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
P019
引用
收藏
页码：S72 / S72
页数：1
相关论文
共 50 条
  • [21] Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings
    Hedin, Charlotte R.
    McCarthy, Neil E.
    Louis, Petra
    Farquharson, Freda M.
    McCartney, Sara
    Taylor, Kirstin
    Prescott, Natalie J.
    Murrells, Trevor
    Stagg, Andrew J.
    Whelan, Kevin
    Lindsay, James O.
    GUT, 2014, 63 (10) : 1578 - 1586
  • [22] Accumulation of multiple γδ T cell clonotypes in the intestinal mucosa from Crohn's disease(CD) patients.
    Kanazawa, H
    Ishiguro, Y
    Munakata, A
    GASTROENTEROLOGY, 1998, 114 (04) : A1006 - A1006
  • [23] Regulation of Gene Related to T Cell Anergy in Lymphocyte (GRAIL) in Patients With Crohn's Disease and Murine Models of Colitis
    Mukai, Akira
    Iijima, Hideki
    Shinzaki, Shinichiro
    Inoue, Takahiro
    Shiraishi, Eri
    Hiyama, Satoshi
    Kawai, Shoichiro
    Tsujii, Masahiko
    Takehara, Tetsuo
    GASTROENTEROLOGY, 2013, 144 (05) : S313 - S313
  • [24] The Crohn's disease candidate gene protein tyrosine phosphatase N2 (PTPN2) is activated by gamma interferon (IFNγ) in intestinal epithelial cells (IECs) in an adenosine-monophosphate kinase (Ampk) dependent manner
    Scharl, Michael
    Barrett, Kim E.
    McCole, Declan F.
    GASTROENTEROLOGY, 2008, 134 (04) : A22 - A22
  • [25] Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease
    Desreumaux, Pierre
    Foussat, Arnaud
    Allez, Matthieu
    Beaugerie, Laurent
    Hebuterne, Xavier
    Bouhnik, Yoram
    Nachury, Maria
    Brun, Valerie
    Bastian, Herve
    Belmonte, Nathalie
    Ticchioni, Michel
    Duchange, Agnes
    Morel-Mandrino, Patricia
    Neveu, Virginie
    Clerget-Chossat, Nathalie
    Forte, Miguel
    Colombel, Jean-Frederic
    GASTROENTEROLOGY, 2012, 143 (05) : 1207 - +
  • [26] Retrospective analysis of Clostridioides difficile and other intestinal infections in patients with Crohn’s disease and ulcerative colitis in the tertiary hospital in Poland. POLIBD survey results
    Jolanta Gruszecka
    Rafał Filip
    Gut Pathogens, 13
  • [27] Retrospective analysis of Clostridioides difficile and other intestinal infections in patients with Crohn's disease and ulcerative colitis in the tertiary hospital in Poland. POLIBD survey results
    Gruszecka, Jolanta
    Filip, Rafal
    GUT PATHOGENS, 2021, 13 (01)
  • [28] T-cell immune response against cytomegalovirus in peripheral blood and colonic mucosa from ulcerative colitis and Crohn's disease patients
    Nam, Seung-Joo
    Kim, Eun Sun
    Jeen, Yoon Tae
    INTESTINAL RESEARCH, 2018, 16 (01) : 160 - 162
  • [29] The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients
    Park, Young Su
    Kang, Sang Bum
    Marchelletta, Ronald R.
    Penrose, Harrison M.
    Ruiter-Visser, Roos
    Jung, Barbara
    Docherty, Michael J.
    Boland, Brigid S.
    Sandborn, William J.
    McCole, Declan F.
    PHARMACEUTICS, 2023, 15 (03)
  • [30] Multigene Analysis Unveils Distinctive Expression Profiles of Helper T-cell-related Genes in the Intestinal Mucosa that Discriminate Between Ulcerative Colitis and Crohn's Disease
    Iboshi, Yoichiro
    Nakamura, Kazuhiko
    Ihara, Eikichi
    Iwasa, Tsutomu
    Akiho, Hirotada
    Harada, Naohiko
    Nakamuta, Makoto
    Takayanagi, Ryoichi
    INFLAMMATORY BOWEL DISEASES, 2014, 20 (06) : 967 - 977
12345