Humanized mice: Current states and perspectives

被引：38
|
作者：
Garcia, Sylvie [1 ]
Freitas, Antonio A. [1 ]
机构：
[1] Inst Pasteur, Unite Biol Populat Lymphocytaires, CNRS URA 1961, F-75724 Paris 015, France
来源：
IMMUNOLOGY LETTERS | 2012年 / 146卷 / 1-2期
关键词：
Humanized mice; Lymphocyte function; HLA; Sirpa; HUMAN IMMUNE-SYSTEM; REGULATORY PROTEIN ALPHA; HUMAN T-CELL; DENGUE VIRUS-INFECTION; BLOOD CD34(+) CELLS; B-CELLS; HIV-1; INFECTION; MOUSE MODEL; SCID MICE; NOG MICE;
D O I：
10.1016/j.imlet.2012.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation of new models of mouse/human chimeras. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 7
页数：7
相关论文
共 50 条
  • [41] Study of viral pathogenesis in humanized mice
    Gaska, Jenna M.
    Ploss, Alexander
    CURRENT OPINION IN VIROLOGY, 2015, 11 : 14 - 20
  • [42] Studies of retroviral infection in humanized mice
    Marsden, Matthew D.
    Zack, Jerome A.
    VIROLOGY, 2015, 479 : 297 - 309
  • [43] Boosting functional hematolymphopoiesis in humanized mice
    Cheng, Tao
    BLOOD, 2006, 108 (02) : 411 - 412
  • [44] Investigation of autoimmune disease in humanized mice
    Trinschek, B.
    Luessi, F.
    Gross, C. C.
    Haas, J.
    Wildemann, B.
    Kurschus, F. C.
    Kuhlmann, T.
    Zipp, F.
    Wiendl, H.
    Becker, C.
    Jonuleit, H.
    EXPERIMENTAL DERMATOLOGY, 2014, 23 (03) : E32 - E32
  • [45] Detection of Human Cytokines in Humanized Mice
    Cherukuri, P.
    Qualy, R.
    Munday, J.
    Frantz, A. M.
    McIntosh, B. E.
    Wilkinson, B.
    Rowse, A. L.
    INTERNATIONAL JOURNAL OF TOXICOLOGY, 2020, 39 (01) : 62 - 63
  • [46] Humanized mice in translational biomedical research
    Shultz, Leonard D.
    Ishikawa, Fumihiko
    Greiner, Dale L.
    NATURE REVIEWS IMMUNOLOGY, 2007, 7 (02) : 118 - 130
  • [47] Genomically humanized mice: technologies and promises
    Anny Devoy
    Rosie K. A. Bunton-Stasyshyn
    Victor L. J. Tybulewicz
    Andrew J. H. Smith
    Elizabeth M. C. Fisher
    Nature Reviews Genetics, 2012, 13 : 14 - 20
  • [48] Genomically humanized mice: technologies and promises
    Devoy, Anny
    Bunton-Stasyshyn, Rosie K. A.
    Tybulewicz, Victor L. J.
    Smith, Andrew J. H.
    Fisher, Elizabeth M. C.
    NATURE REVIEWS GENETICS, 2012, 13 (01) : 14 - 20
  • [49] Humanized mice to test influenza vaccines
    Yu, Chun
    Gallegos, Mike
    Marches, Florentina
    Zurawski, Sandra
    Zurawski, Gerard
    Banchereau, Jacques
    Palucka, A. Karolina
    CLINICAL IMMUNOLOGY, 2008, 127 : S30 - S30
  • [50] Translating Treg Therapy in Humanized Mice
    Hahn, Susanne A.
    Bellinghausen, Iris
    Trinschek, Bettina
    Becker, Christian
    FRONTIERS IN IMMUNOLOGY, 2015, 6
12345