Humanized mice: Current states and perspectives

被引：38
|
作者：
Garcia, Sylvie [1 ]
Freitas, Antonio A. [1 ]
机构：
[1] Inst Pasteur, Unite Biol Populat Lymphocytaires, CNRS URA 1961, F-75724 Paris 015, France
来源：
IMMUNOLOGY LETTERS | 2012年 / 146卷 / 1-2期
关键词：
Humanized mice; Lymphocyte function; HLA; Sirpa; HUMAN IMMUNE-SYSTEM; REGULATORY PROTEIN ALPHA; HUMAN T-CELL; DENGUE VIRUS-INFECTION; BLOOD CD34(+) CELLS; B-CELLS; HIV-1; INFECTION; MOUSE MODEL; SCID MICE; NOG MICE;
D O I：
10.1016/j.imlet.2012.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation of new models of mouse/human chimeras. (c) 2012 Elsevier B.V. All rights reserved.
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页码：1 / 7
页数：7
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