ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae)

被引：26
|
作者：
Santana, Jeferson S. [1 ]
Sartorelli, Patricia [1 ]
Lago, Joao Henrique G. [1 ]
Matsuo, Alisson L. [2 ]
机构：
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
[2] Univ Fed Sao Paulo, Dept Micro Imuno & Parasitol, BR-04023062 Sao Paulo, SP, Brazil
来源：
QUIMICA NOVA | 2012年 / 35卷 / 11期
关键词：
Schinus terebinthifolius; phenolic derivatives; cytotoxic activity; CHEMICAL-COMPOSITION; ESSENTIAL OILS; CONSTITUENTS; APOPTOSIS; BERRIES; GROWTH; LEAVES; ACID;
D O I：
10.1590/S0100-40422012001100029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae). The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.
引用
收藏
页码：2245 / 2248
页数：4
相关论文
共 50 条
  • [41] Clinical and Microbiological Evaluation of the Treatment of Denture Stomatitis with Schinus terebinthifolius Raddi (Aroeira) Tincture
    de Sousa Soares, Diana Gabriela
    de Oliveira, Cibele Braga
    Paulo, Marcal de Queiroz
    Farias Peixoto Carvalho, Maria de Fatima
    Nascimento Padilha, Wilton Wilney
    PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA, 2010, 10 (03): : 365 - 370
  • [42] The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction
    Nunes-Neto, Paulo Alexandre
    da Silva Peixoto-Sobrinho, Tadeu Jose
    da Silva Junior, Edilson Dantas
    da Silva, Jamilka Leopoldina
    da Silva Oliveira, Alisson Rodrigo
    Pupo, Andre Sampaio
    Araujo, Alice Valenca
    da Costa-Silva, Joao Henrique
    Wanderley, Almir Goncalves
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 2017
  • [43] Fatty Acids Constituents of Wood from Schinus terebinthifolius Raddi using GC Analysis
    Salem, Mohamed Z. M.
    El-Shikh, Mohamed S.
    Ali, Hayssam M.
    JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2014, 8 (01): : 205 - 209
  • [44] Pressurized liquid extraction of anthocyanins and biflavonoids from Schinus terebinthifolius Raddi: A multivariate optimization
    Feuereisen, Michelle M.
    Barraza, Mariana Gamero
    Zimmermann, Benno F.
    Schieber, Andreas
    Schulze-Kaysers, Nadine
    FOOD CHEMISTRY, 2017, 214 : 564 - 571
  • [45] Cytotoxic and antibacterial compounds from Schinus terebinthifolia Raddi fruits
    Pardo, Jennifer Blandon
    David, Jorge Mauricio
    Barros, Alef
    Barreto, Emiliano
    NATURAL PRODUCT RESEARCH, 2024,
  • [46] The perception of Naturology students from inhaling the pink pepper essential oil (Schinus terebinthifolius Raddi)
    Zago Wang, Juliana Huei
    Dare, Patricia Kozuchovski
    Emer, Aline Armiliato
    FLAVOUR AND FRAGRANCE JOURNAL, 2021, 36 (05) : 593 - 604
  • [47] Exploring the antiparasitic and antimicrobial potential of Schinus terebinthifolius Raddi essential oil against fish and shrimp pathogens
    Pereira Junior, Jucimauro de Araujo
    dos Santos, Gracienhe Gomes
    Costa, Domickson Silva
    Silva, Graziella Vivine Goncalves de Matos
    dos Santos, Paola Capistrano
    dos Anjos, Gabriele Bueno
    de Moraes, Luiz Felipe Kretzer
    Cardoso, Claudia Andrea Lima
    Ventura, Arlene Sobrinho
    Sousa, Natalino da Costa
    Martins, Mauricio Laterca
    JOURNAL OF FISH DISEASES, 2024, 47 (11)
  • [48] Optimization of hydrodistillation and in vitro anticancer activity of essential oil from Schinus terebinthifolius Raddi fruits
    da Silva, Bruno Guzzo
    Foglio, Mary Ann
    Vieira e Rosa, Paulo de Tarso
    Taranto, Osvaldir Pereira
    Frattini Fileti, Ana Maria
    CHEMICAL ENGINEERING COMMUNICATIONS, 2019, 206 (05) : 619 - 629
  • [49] Microwave turbo hydrodistillation for rapid extraction of the essential oil from Schinus terebinthifolius Raddi Berries
    Perino-Issartier, Sandrine
    Abert-Vian, Maryline
    Petitcolas, Emmanuel
    Chemat, Farid
    CHROMATOGRAPHIA, 2010, 72 (3-4) : 347 - 350
  • [50] Characterization of flours from the aroeira leaf ( Schinus terebinthifolius Raddi), obtained by different drying methods
    Silva, Jordania Candice Costa
    Santos, Nayane Medeiros
    de Sousa Silva, Nayara
    Martins, Ana Cristina Silveira
    Dutra, Larissa Maria Gomes
    Dantas, Carlos Eduardo Alves
    dos Santos Lima, Marcos
    Tavares, Josean Fechine
    da Silva, Marcelo Sobral
    do Nascimento, Yuri Mangueira
    da Silva, Evandro Ferreira
    de Oliveira, Carlos Eduardo Vasconcelos
    de Oliveira, Maria Elieidy Gomes
    Pereira, Diego Elias
    dos Santos Costa, Ana Carolina
    Freitas, Juliano Carlo Rufino
    Soares, Juliana Kessia Barbosa
    Viera, Vanessa Bordin
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2024, 1239
12345