ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae)

被引：26
|
作者：
Santana, Jeferson S. [1 ]
Sartorelli, Patricia [1 ]
Lago, Joao Henrique G. [1 ]
Matsuo, Alisson L. [2 ]
机构：
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
[2] Univ Fed Sao Paulo, Dept Micro Imuno & Parasitol, BR-04023062 Sao Paulo, SP, Brazil
来源：
QUIMICA NOVA | 2012年 / 35卷 / 11期
关键词：
Schinus terebinthifolius; phenolic derivatives; cytotoxic activity; CHEMICAL-COMPOSITION; ESSENTIAL OILS; CONSTITUENTS; APOPTOSIS; BERRIES; GROWTH; LEAVES; ACID;
D O I：
10.1590/S0100-40422012001100029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae). The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.
引用
收藏
页码：2245 / 2248
页数：4
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