Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

被引：176
|
作者：
Momose, Y
Murata, M
Kobayashi, K
Tachikawa, M
Nakabayashi, Y
Kanazawa, I
Toda, T
机构：
[1] Osaka Univ, Grad Sch Med, Dept Postgen & Dis, Div Funct Gen, Suita, Osaka 5650871, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Neurol, Tokyo, Japan
来源：
ANNALS OF NEUROLOGY | 2002年 / 51卷 / 01期
关键词：
D O I：
10.1002/ana.10079
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the SI8Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
引用
收藏
页码：133 / 136
页数：4
相关论文
共 50 条
  • [41] Towards high-throughput association studies using single nucleotide polymorphisms
    Novik, KLT
    Ponder, BAJP
    JOURNAL OF MEDICAL GENETICS, 2000, 37 : S70 - S70
  • [42] Association of single nucleotide polymorphisms in inflammatory candidate genes with circulating inflammatory biomarker concentrations: The Framingham Heart Study
    Schnabel, Renate
    Lunetta, Kathryn L.
    Larson, Martin G.
    Dupuis, Josee
    Keaney, John F.
    Lipinska, Izabella
    Govindaraju, Diddahally R.
    Hirschhorn, Joel N.
    Kathiresan, Sekar
    Meigs, James B.
    Lee, Douglas S.
    O'Donnell, Christopher J.
    Newton-Cheh, Christopher
    Chen, Ming-Huei
    Zhao, Zhenming
    Rong, Jian
    Sutherland, Patrice
    Vasan, Ramachandran S.
    Benjamin, Emelia J.
    CIRCULATION, 2007, 116 (16) : 39 - 39
  • [43] Association study between single nucleotide polymorphisms in candidate genes and reproduction traits in Italian Large White sows
    Dall'Olio, S.
    Fontanesi, L.
    Buttazzoni, L.
    Baiocco, C.
    Gallo, M.
    Russo, V.
    LIVESTOCK SCIENCE, 2013, 155 (2-3) : 172 - 179
  • [44] Single-nucleotide polymorphisms in the promoter region of the PARKIN gene and Parkinson's disease
    Mata, IF
    Alvarez, V
    García-Moreira, V
    Guisasola, LM
    Ribacoba, R
    Salvador, C
    Blázquez, M
    Sarmiento, RG
    Lahox, CH
    Menes, BB
    García, EC
    NEUROSCIENCE LETTERS, 2002, 329 (02) : 149 - 152
  • [45] Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome
    H. Iwasa
    M. Kurabayashi
    R. Nagai
    Y. Nakamura
    T. Tanaka
    Journal of Human Genetics, 2001, 46 : 158 - 162
  • [46] Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome
    Iwasa, H
    Kurabayashi, M
    Nagai, R
    Nakamura, Y
    Tanaka, T
    JOURNAL OF HUMAN GENETICS, 2001, 46 (03) : 158 - 162
  • [47] Associations of fifty single nucleotide polymorphisms within candidate genes with meatness in pigs
    Borowska, A.
    Szwaczkowski, T.
    Kocwin-Podsiadla, M.
    Kaminski, S.
    Rusc, A.
    Krzecio-Nieczyporuk, E.
    CZECH JOURNAL OF ANIMAL SCIENCE, 2014, 59 (05) : 227 - 237
  • [48] Novel single nucleotide polymorphisms in candidate genes for growth in tilapia (Oreochromis niloticus)
    Lizeth Cuevas-Rodriguez, Breidy
    Maria Sifuentes-Rincon, Ana
    Ambriz-Morales, Pascuala
    Garcia-Ulloa, Manuel
    Javier Valdez-Gonzalez, Francisco
    Rodriguez-Gonzalez, Hervey
    REVISTA BRASILEIRA DE ZOOTECNIA-BRAZILIAN JOURNAL OF ANIMAL SCIENCE, 2016, 45 (06): : 345 - 348
  • [49] Analysis of single nucleotide polymorphisms in candidate genes for hypertension and insulin resistance.
    Olivier, M
    Sheu, HHW
    Jeng, CY
    Hsiao, CF
    Tseng, YZ
    Ranade, K
    Chen, YDI
    Olshen, R
    Curb, D
    Pratt, R
    Jarvis, N
    Indig, MD
    Risch, N
    Cox, DR
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A438 - A438
  • [50] Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats
    Bressani, F. A.
    Tizioto, P. C.
    Giglioti, R.
    Meirelles, S. L. C.
    Coutinho, R.
    Benvenuti, C. L.
    Malago-, W., Jr.
    Mudadu, M. A.
    Vieira, L. S.
    Zaros, L. G.
    Carrilho, E.
    Regitano, L. C. A.
    GENETICS AND MOLECULAR RESEARCH, 2014, 13 (04) : 8530 - 8536
12345