Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

被引：176
|
作者：
Momose, Y
Murata, M
Kobayashi, K
Tachikawa, M
Nakabayashi, Y
Kanazawa, I
Toda, T
机构：
[1] Osaka Univ, Grad Sch Med, Dept Postgen & Dis, Div Funct Gen, Suita, Osaka 5650871, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Neurol, Tokyo, Japan
来源：
ANNALS OF NEUROLOGY | 2002年 / 51卷 / 01期
关键词：
D O I：
10.1002/ana.10079
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the SI8Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
引用
收藏
页码：133 / 136
页数：4
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