Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

被引：15

作者：

Jiang, Hai Yan ^{[1
]}

Wang, Cheng Fang ^{[2
]}

Fan, Li ^{[3
]}

Yang, Kai ^{[2
]}

Feng, Jiang Bin ^{[3
]}

Geng, Zhu Feng ^{[4
]}

Xu, Jing ^{[1
]}

Deng, Zhi Wei ^{[4
]}

Du, Shu Shan ^{[2
]}

Yin, Hai Bo ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Liaoning, Peoples R China

[2] Beijing Normal Univ, State Key Lab Earth Surface Proc & Resource Ecol, Beijing 100875, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Key Lab Radiol Protect & Nucl Emergency, Beijing 100875, Peoples R China

[4] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China

来源：

MOLECULES | 2013年 / 18卷 / 09期

关键词：

8-geranyloxypsolaren; 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde; Clausena lansium; carbazoles; coumarins; cytotoxic activity; CARBAZOLE ALKALOIDS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL-ACTIVITY; COUMARINS; DERIVATIVES; INHIBITORS; EXCAVATA; AGENTS;

D O I：

10.3390/molecules180910768

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4-6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC50 values of 6.19 to 26.84 mu g/mL.

引用

页码：10768 / 10775

页数：8

共 50 条

[41] FURANOCOUMARINS AND SESQUITERPENE KETONE FROM CLAUSENA-LANSIUM SKEELS
LI, WS
MCCHESNEY, JD
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1990, 37 (06) : 571 - 575
[42] Bioactive furanocoumarins from stems of Clausena lansium
Liu, Hang
Li, Fei
Li, Chuang-Jun
Yang, Jing-Zhi
Li, Li
Chen, Nai-Hong
Zhang, Dong-Ming
PHYTOCHEMISTRY, 2014, 107 : 141 - 147
[43] Effects of UV-C irradiation on postharvest quality and antioxidant properties of wampee fruit (Clausena lansium (Lour.) Skeels) during cold storage
Zeng, J. K.
Jiang, Z. T.
Li, W.
Zhang, L. B.
Shao, Y. Z.
FRUITS, 2020, 75 (01) : 36 - 43
[44] Bioactive carbazole alkaloids from the stems of Clausena lansium
Du, Yi-Qian
Liu, Hang
Li, Chuang-Jun
Ma, Jie
Zhang, Dan
Li, Li
Sun, Hua
Bao, Xiu-Qi
Zhang, Dong-Ming
FITOTERAPIA, 2015, 103 : 122 - 128
[45] Structural characterization of a water-soluble acidic polysaccharide CSP-IV with potential anticoagulant activity from fruit pulp of Clausena lansium (Lour.) Skeels Guifei
Wu, Jiayi
Zheng, Wenyan
Luo, Ping
Lin, Zhen
Li, Fangping
Liang, Linlin
Liu, Huazhong
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 254
[46] Anti-inflammatoty constituents from the stems of Aglaia odorata Lour.
Kim, Y. M.
Seo, J. S.
Oh, S. R.
Lee, H. K.
Chin, Y. W.
PLANTA MEDICA, 2012, 78 (11) : 1242 - 1242
[47] The Constituents from the Stem of Clausena lansium and their Bioactivities
Wu, T.
Shen, D.
Chao, C.
Chan, H.
Lin, W.
Lee, K.
Thang, T.
PLANTA MEDICA, 2011, 77 (12) : 1353 - 1353
[48] Carbazole and amide alkaloids from the stems of Clausena lansium
Du, Yi-Qian
Liu, Hang
Li, Chuang-Jun
Yang, Jing-Zhi
Ma, Jie
Zhang, Dan
Sun, Hua
Zhang, Dong-Ming
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 17 (11) : 1048 - 1053
[49] Cytotoxic Amides and Quinolones from Clausena lansium
Song, Wei-Wu
Zeng, Guang-Zhi
Peng, Wen-Wen
Chen, Ke-Xian
Tan, Ning-Hua
HELVETICA CHIMICA ACTA, 2014, 97 (02) : 298 - 305
[50] Carbazole alkaloids with bioactivities from the stems of Clausena lansium
Sun, Xing-Yan
Ma, Jie
Li, Chuang-Jun
Zang, Ying-Da
Huang, Ji-Wu
Wang, Xu-Yan
Chen, Nai-Hong
Chen, Xiao-Guang
Zhang, Dong-Ming
PHYTOCHEMISTRY LETTERS, 2020, 38 : 28 - 32

← 1 2 3 4 5 →