Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

被引：15
|
作者：
Jiang, Hai Yan [1 ]
Wang, Cheng Fang [2 ]
Fan, Li [3 ]
Yang, Kai [2 ]
Feng, Jiang Bin [3 ]
Geng, Zhu Feng [4 ]
Xu, Jing [1 ]
Deng, Zhi Wei [4 ]
Du, Shu Shan [2 ]
Yin, Hai Bo [1 ]
机构：
[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Liaoning, Peoples R China
[2] Beijing Normal Univ, State Key Lab Earth Surface Proc & Resource Ecol, Beijing 100875, Peoples R China
[3] Chinese Ctr Dis Control & Prevent, Key Lab Radiol Protect & Nucl Emergency, Beijing 100875, Peoples R China
[4] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China
来源：
MOLECULES | 2013年 / 18卷 / 09期
关键词：
8-geranyloxypsolaren; 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde; Clausena lansium; carbazoles; coumarins; cytotoxic activity; CARBAZOLE ALKALOIDS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL-ACTIVITY; COUMARINS; DERIVATIVES; INHIBITORS; EXCAVATA; AGENTS;
D O I：
10.3390/molecules180910768
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4-6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC50 values of 6.19 to 26.84 mu g/mL.
引用
收藏
页码：10768 / 10775
页数：8
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