Structural and biological studies of new monomeric, tetrameric, and polymeric organotin(IV) esters of 3-(benzo[d][1,3]dioxol-4-yl)propanoic acid

被引：12
|
作者：
Hussain, Mukhtiar [1 ]
Zia-Ur-Rehman [1 ]
Ahmad, Muhammad Sheeraz [2 ]
Altaf, Muhammad [3 ]
Stoeckli-Evans, Helen [3 ]
Ali, Saqib [1 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Quaid I Azam Univ, Dept Biochem, Fac Biol Sci, Islamabad 45320, Pakistan
[3] Univ Neuchatel, Inst Phys, CH-2009 Neuchatel, Switzerland
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2013年 / 66卷 / 05期
关键词：
Organotin(IV) carboxylates; Spectroscopic studies; X-ray crystallography; Biological screening; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; COMPLEXES; DERIVATIVES; CHEMISTRY; DIORGANOTIN(IV); CARBOXYLATES;
D O I：
10.1080/00958972.2013.770845
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Six new monomeric, tetrameric, and polymeric organotin(IV) derivatives of sodium 3-(benzo[d][1,3]dioxol-4-yl)propanoate (NaL) have been synthesized and characterized by various analytical techniques. These compounds show different structural behavior in solution and solid state as confirmed by NMR and X-ray single-crystal analysis. Antimicrobial and antitumor activities are mainly governed by diffusion, lipophilicity, geometry, and steric factors. The high antitumor and antifungal activities of some of these organotin compounds demand further investigations to commercialize them as new tin-based drugs.
引用
收藏
页码：868 / 880
页数：13
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