Synthesis, antitubercular and antifungal activities of heteroaryl-substituted oxiranes derived from Baylis-Hillman adducts

被引：8

作者：

Jain, Shubha ^{[1
]}

Babu, Neelaiah ^{[1
]}

Jetti, Srinivasa Rao ^{[1
]}

Shah, Harshada ^{[2
]}

Dhaneria, Surya Prakash ^{[3
]}

机构：

[1] Vikram Univ, Lab Heterocycles, Sch Studies Chem & Biochem, Ujjain 456010, Madhya Pradesh, India

[2] RD Gardi Med Coll, Dept Microbiol, Ujjain 456001, Madhya Pradesh, India

[3] RD Gardi Med Coll, Dept Pharmacol, Ujjain 456001, Madhya Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期

关键词：

Baylis-Hillman adducts; Heteroaryl-substituted oxiranes; Antifungal; Antitubercular activity; POTENTIAL ANTIALLERGY AGENTS; DERIVATIVES; ESTERS; ACETATES; ANALOGS;

D O I：

10.1007/s00044-011-9802-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of heteroaryl-substituted oxiranes (2a-2f) were synthesized in good yields by epoxidation of Baylis-Hillman adducts (1a-1f). The title compounds were evaluated for their invitro antifungal and antitubercular activities at various concentrations.

引用

页码：2744 / 2748

页数：5

共 50 条

[1] Synthesis, antitubercular and antifungal activities of heteroaryl-substituted oxiranes derived from Baylis–Hillman adducts
Shubha Jain
Neelaiah Babu
Srinivasa Rao Jetti
Harshada Shah
Surya Prakash Dhaneria
Medicinal Chemistry Research, 2012, 21 : 2744 - 2748
[2] The first successful intermolecular Heck reaction of Baylis-Hillman adducts:: synthesis of β-aryl substituted Baylis-Hillman adducts
Kim, Jeong Mi
Kim, Ko Hoon
Kim, Taek Hyeon
Kim, Jae Nyoung
TETRAHEDRON LETTERS, 2008, 49 (20) : 3248 - 3251
[3] An expedient synthesis of β-phenyl substituted Baylis-Hillman and Aza-Baylis-Hillman adducts
Kim, Seong Jin
Lee, Hyun Seung
Kim, Jeong Mi
Kim, Jae Nyoung
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2008, 29 (01): : 265 - 268
[4] Synthesis of substituted uracil derivatives from the acetates of the Baylis-Hillman adducts
Lee, CG
Gowrisankar, S
Kim, JN
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2005, 26 (03) : 481 - 484
[5] Synthesis of substituted maleimide derivatives using the Baylis-Hillman adducts
Basavaiah, Deevi
Lenin, Dandamudi V.
Veeraraghavaiah, Gorre
CURRENT SCIENCE, 2011, 101 (07): : 888 - 893
[6] Synthesis of poly-substituted pyrroles starting from the Baylis-Hillman adducts
Lee, Hyun Seung
Kim, Jeong Mi
Kim, Jae Nyoung
TETRAHEDRON LETTERS, 2007, 48 (23) : 4119 - 4122
[7] An expedient synthesis of 2-substituted naphthalenes from the Baylis-Hillman adducts
Kim, JN
Im, YJ
Gong, JH
Lee, KY
TETRAHEDRON LETTERS, 2001, 42 (25) : 4195 - 4197
[8] An expeditious synthesis of substituted pyrrolidines and tetrahydrofurans starting from baylis-hillman adducts
Gowrisankar, Saravanan
Kim, Hoo Sook
Lee, Hyun Seung
Kim, Jae Nyoung
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (10): : 1844 - 1846
[9] Regioselective synthesis of poly-substituted thiophenes from Baylis-Hillman adducts
Lee, Hyun Seung
Kim, Se Hee
Kim, Jae Nyoung
TETRAHEDRON LETTERS, 2009, 50 (47) : 6480 - 6483
[10] Synthesis of cyclic compounds from the Baylis-Hillman adducts
Kim, JN
Lee, KY
CURRENT ORGANIC CHEMISTRY, 2002, 6 (07) : 627 - 645

← 1 2 3 4 5 →