Synthesis, antitubercular and antifungal activities of heteroaryl-substituted oxiranes derived from Baylis-Hillman adducts

被引：8
|
作者：
Jain, Shubha [1 ]
Babu, Neelaiah [1 ]
Jetti, Srinivasa Rao [1 ]
Shah, Harshada [2 ]
Dhaneria, Surya Prakash [3 ]
机构：
[1] Vikram Univ, Lab Heterocycles, Sch Studies Chem & Biochem, Ujjain 456010, Madhya Pradesh, India
[2] RD Gardi Med Coll, Dept Microbiol, Ujjain 456001, Madhya Pradesh, India
[3] RD Gardi Med Coll, Dept Pharmacol, Ujjain 456001, Madhya Pradesh, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Baylis-Hillman adducts; Heteroaryl-substituted oxiranes; Antifungal; Antitubercular activity; POTENTIAL ANTIALLERGY AGENTS; DERIVATIVES; ESTERS; ACETATES; ANALOGS;
D O I：
10.1007/s00044-011-9802-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of heteroaryl-substituted oxiranes (2a-2f) were synthesized in good yields by epoxidation of Baylis-Hillman adducts (1a-1f). The title compounds were evaluated for their invitro antifungal and antitubercular activities at various concentrations.
引用
收藏
页码：2744 / 2748
页数：5
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