SPME-GC-MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case

被引：56
|
作者：
Saito, Takeshi [1 ]
Namera, Akira [2 ]
Osawa, Motoki [3 ]
Aoki, Hiromichi [1 ]
Inokuchi, Sadaki [1 ]
机构：
[1] Tokai Univ, Dept Emergency & Crit Care Med, Sch Med, Isehara, Kanagawa 2591143, Japan
[2] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Forens Med, Minami Ku, Hiroshima 7348551, Japan
[3] Tokai Univ, Dept Forens Med, Sch Med, Isehara, Kanagawa 2591143, Japan
来源：
FORENSIC TOXICOLOGY | 2013年 / 31卷 / 02期
关键词：
alpha-Pyrrolidinovaleorophenone; Designer drug; Gas chromatography-mass spectrometry; Poisoning; DRUGS;
D O I：
10.1007/s11419-013-0183-8
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
We provided toxicological analytical support for a fatal case of abuse of alpha-pyrrolidinovaleorophenone (alpha-PVP). Solid-phase microextraction (SPME) and capillary gas chromatography coupled to mass spectrometry (GC-MS) was employed to quantify the drug in whole blood. The whole blood concentration of the drug in the heart was 486 ng/ml. This is the first report of alpha-PVP intoxication as ascertained by mass spectrometric identification of alpha-PVP in whole blood.
引用
收藏
页码：328 / 332
页数：5
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