A Convenient Synthesis of Novel Functionalized Pyrimido[5′,4′:4,5]thieno[3,2-c]pyridazines and Related Fused Systems

被引：3

作者：

Aly, A. A. ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Banha, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 12期

关键词：

Antimicrobial activities; pyrimidothienopyridazines; pyridazinothienotriazines; pyridothienopyridazines; thieno[3; 2-c]pyridazine;

D O I：

10.1080/10426500802060040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Possible approaches to the synthesis of functionalized, pyrimido[5',4':4,5]thieno [3,2-c]pyridazines 2-18, pyridazino[3',4':4,5]thieno[2,3-d]triazines 19, 20a,b and pyrido[3',2':4,5]thieno[3,2-c]pyridazines 22a,b are described. The sequence involves the heterocyclization of 6-amino-1,3-diphenyl-1,4-dihydrothieno[3,2-c]pyridazine-7-carboxamide (1) with appropriate reagents. The antimicrobial activity of some the newly synthesized compounds was examined. All tested compounds proved to be active as antibacterial and antifungal agents.

引用

页码：3079 / 3096

页数：18

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