A Convenient Synthesis of Novel Functionalized Pyrimido[5′,4′:4,5]thieno[3,2-c]pyridazines and Related Fused Systems

被引：3

作者：

Aly, A. A. ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Banha, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 12期

关键词：

Antimicrobial activities; pyrimidothienopyridazines; pyridazinothienotriazines; pyridothienopyridazines; thieno[3; 2-c]pyridazine;

D O I：

10.1080/10426500802060040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Possible approaches to the synthesis of functionalized, pyrimido[5',4':4,5]thieno [3,2-c]pyridazines 2-18, pyridazino[3',4':4,5]thieno[2,3-d]triazines 19, 20a,b and pyrido[3',2':4,5]thieno[3,2-c]pyridazines 22a,b are described. The sequence involves the heterocyclization of 6-amino-1,3-diphenyl-1,4-dihydrothieno[3,2-c]pyridazine-7-carboxamide (1) with appropriate reagents. The antimicrobial activity of some the newly synthesized compounds was examined. All tested compounds proved to be active as antibacterial and antifungal agents.

引用

页码：3079 / 3096

页数：18

共 50 条

[21] Synthesis of Derivatives of Cyclopenta[4',5']Pyrido-[3',2':4,5]Thieno[3,2-d]Pyrimidines and Pyrimido[5',4':2,3]-Thieno[2,3-c]Isoquinolines
Paronikyan, E. G.
Dashyan, Sh. Sh.
Noravyan, A. S.
Minasyan, N. S.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 50 (08) : 1188 - 1194
[22] SYNTHESIS OF PYRROLO[2',3'-4,5]FURO[3,2-C]PYRIDINES
BENCKOVA, M
KRUTOSIKOVA, A
MONATSHEFTE FUR CHEMIE, 1995, 126 (6-7): : 753 - 758
[23] Fused pyridothienopyrimidine heterocycles. 2*. A facile and efficient synthesis of the annelated pyrido[3′,2′:4,5]thieno-[2,3-e]pyrimido[3,2-c]pyrimidones
F. A. El-Essawy
Chemistry of Heterocyclic Compounds, 2009, 45 : 837 - 843
[24] Synthesis of 5,8-Diamino-Substituted Pyrano[4aEuro3,3aEuro3:4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrimido[4',5':4,5]thieno[2,3-c]isoquinolines
Paronikyan, E. G.
Dashyan, Sh. Sh.
Minasyan, N. S.
Stepanyan, G. M.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (04) : 576 - 581
[25] A CONVENIENT SYNTHESIS OF THE THIENO[3,2-C]PYRIDINE NUCLEUS
WIKEL, JH
DENNEY, ML
VASILEFF, RT
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (01) : 289 - 290
[26] Novel syntheses of 5-aminothieno[2,3-c]pyridazine, pyrimido[4',5':4,5]thieno[2,3-c]pyridazine, pyridazino[4',3':4,5]thieno[3,2-d][1,2,3]triazine and phthalazine derivatives
El-Gaby, MSA
El-Dean, AMK
Gaber, AEM
Eyada, HA
Al-Kamali, ASN
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2003, 24 (08) : 1181 - 1187
[27] Synthesis of some pyrimido[4',5':4,5]thieno[2,3-b]quinolines and related heterocycles
Hafez, AAA
ElDean, AK
Hassan, AA
ElKashef, HS
Rault, S
Robba, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (02) : 431 - 438
[28] Synthesis of some Pyrimido[4',5':4,5]thieno[2,3-b]quinolines and Related Heterocycles
J Heterocycl Chem, 2 (431):
[29] SYNTHESIS OF 2,3-DIHYDRO-IMIDAZO[1,2-C]PYRIMIDO[5',4'-4,5]THIEN[2,3-E]PYRIMIDINES AND 2H-3,4-DIHYDRO-PYRIMIDO[1,2-C]PYRIMIDO[5',4'-4,5]THIENO[2,3-E]PYRIMIDINES
WAGNER, G
VIEWEG, H
LEISTNER, S
PHARMAZIE, 1993, 48 (08): : 588 - 591
[30] REACTIONS OF ETHYL 4,5-DIHYDRO-4-OXOTHIENO[3,2-C]PYRIDINE-6-CARBOXYLATE - SYNTHESIS OF NEW THIENO[3,2-C]PYRIDINE DERIVATIVES AND THIENO[2',3'-4,5]PYRIDINO[1,2-D]-AS-TRIAZINES
HASSAN, MA
ELBORAI, M
SALEM, MAI
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1982, 21 (02): : 112 - 114

← 1 2 3 4 5 →