A Convenient Synthesis of Novel Functionalized Pyrimido[5′,4′:4,5]thieno[3,2-c]pyridazines and Related Fused Systems

被引：3
|
作者：
Aly, A. A. [1 ]
机构：
[1] Benha Univ, Fac Sci, Dept Chem, Banha, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 12期
关键词：
Antimicrobial activities; pyrimidothienopyridazines; pyridazinothienotriazines; pyridothienopyridazines; thieno[3; 2-c]pyridazine;
D O I：
10.1080/10426500802060040
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Possible approaches to the synthesis of functionalized, pyrimido[5',4':4,5]thieno [3,2-c]pyridazines 2-18, pyridazino[3',4':4,5]thieno[2,3-d]triazines 19, 20a,b and pyrido[3',2':4,5]thieno[3,2-c]pyridazines 22a,b are described. The sequence involves the heterocyclization of 6-amino-1,3-diphenyl-1,4-dihydrothieno[3,2-c]pyridazine-7-carboxamide (1) with appropriate reagents. The antimicrobial activity of some the newly synthesized compounds was examined. All tested compounds proved to be active as antibacterial and antifungal agents.
引用
收藏
页码：3079 / 3096
页数：18
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