Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide

被引：16

作者：

Murthy, Y. L. N. ^{[1
]}

Rajack, Abdul ^{[1
,2
]}

Yuvaraj, Kanithi ^{[1
]}

机构：

[1] Andhra Univ, Dept Organ Chem Foods Drugs & Water, Visakhapatnam 530003, Andhra Pradesh, India

[2] MVGR Coll Engn, Dept Sci & Humanities, Vijayanagaram 535005, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷

关键词：

N; O-Bis(trimethylsilyl)acetamide; Dicyclohexyl carbodimide; Solvent free; 3,4-Dihydropyrimidinones; 3,4-Dihydropyrimidithiones; ONE-POT SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; BIGINELLI-TYPE; EFFICIENT SYNTHESIS; REUSABLE CATALYST; GREEN APPROACH; ACID-ESTERS; DIHYDROPYRIMIDINONES; CONDENSATION; 3-COMPONENT;

D O I：

10.1016/j.arabjc.2012.04.046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein, the usage of N,O-bis(trimethylsilyl) acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 degrees C to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones/thiones (DHPMs) in good to excellent yields. A comparative study of these two catalysts was made and presented. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S1740 / S1746

页数：7

共 50 条

[31] Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions
Asghari, Sekineh
Tajbakhsh, Mahmood
Kenari, Behnam Jafarzadeh
Khaksar, Samad
CHINESE CHEMICAL LETTERS, 2011, 22 (02) : 127 - 130
[32] New Substituted 1-Aryl-4,4,6-Trimethyl-3,4-Dihydropyrimidine-2-(1H)Thiones; A Metal-Free and Solvent-Free Synthesis, Characterization, and Lymphoid Tyrosine Phosphatase Inhibition Studies
Khurshid, Asma
Saeed, Aamer
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2017, 64 (02) : 224 - 230
[33] Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions
Sekineh Asghari
Mahmood Tajbakhsh
Behnam Jafarzadeh Kenari
Samad Khaksar
ChineseChemicalLetters, 2011, 22 (02) : 127 - 130
[34] One-Pot Syntheses of 3,4-Dihydropyrimidine-2（1H）-thiones Catalyzed by La（OTf）3
陈瑞芳
钱长涛
ChineseJournalofChemistry, 2002, (05) : 427 - 430
[35] One-pot syntheses of 3,4-dihydropyrimidine-2(1H)-thiones catalyzed by La(OTf)3
Chen, RF
Qian, CT
CHINESE JOURNAL OF CHEMISTRY, 2002, 20 (05) : 427 - 430
[36] Synthesis of thiazolo[3,2-a]pyrimidines from 3,4-dihydropyrimidine-2(1H)-thiones
M. M. Kurbanova
Russian Journal of Organic Chemistry, 2006, 42 : 1871 - 1872
[37] SYNTHESIS OF 5-CINNAMOYL-3,4-DIHYDROPYRIMIDINE-2(1H)-ONES
Kolosov, Maksim A.
Kulyk, Olesia G.
Shvets, Elena G.
Orlov, Valeriy D.
SYNTHETIC COMMUNICATIONS, 2014, 44 (11) : 1649 - 1657
[38] Synthesis of thiazolo[3,2-a]pyrimidines from 3,4-dihydropyrimidine-2(1H)-thiones
Kurbanova, M. M.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (12) : 1871 - 1872
[39] A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO2 Under Solvent-Free Conditions
Gawande, Manoj B.
Nagrik, Deepak M.
Ambhore, Damodar M.
LETTERS IN ORGANIC CHEMISTRY, 2012, 9 (01) : 12 - 18
[40] Scalable synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent free condition
Kataki, Dolly
Chakraborty, Pranita
Sarmah, Pubalee
Phukan, Prodeep
INDIAN JOURNAL OF CHEMICAL TECHNOLOGY, 2006, 13 (05) : 519 - 521

← 1 2 3 4 5 →