Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide

被引：16

作者：

Murthy, Y. L. N. ^{[1
]}

Rajack, Abdul ^{[1
,2
]}

Yuvaraj, Kanithi ^{[1
]}

机构：

[1] Andhra Univ, Dept Organ Chem Foods Drugs & Water, Visakhapatnam 530003, Andhra Pradesh, India

[2] MVGR Coll Engn, Dept Sci & Humanities, Vijayanagaram 535005, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷

关键词：

N; O-Bis(trimethylsilyl)acetamide; Dicyclohexyl carbodimide; Solvent free; 3,4-Dihydropyrimidinones; 3,4-Dihydropyrimidithiones; ONE-POT SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; BIGINELLI-TYPE; EFFICIENT SYNTHESIS; REUSABLE CATALYST; GREEN APPROACH; ACID-ESTERS; DIHYDROPYRIMIDINONES; CONDENSATION; 3-COMPONENT;

D O I：

10.1016/j.arabjc.2012.04.046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein, the usage of N,O-bis(trimethylsilyl) acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 degrees C to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones/thiones (DHPMs) in good to excellent yields. A comparative study of these two catalysts was made and presented. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S1740 / S1746

页数：7

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