Cytochrome P450 enzymes in drug metabolism and chemical toxicology

被引：116
|
作者：
Furge, LL
Guengerich, FP
机构：
[1] Kalamazoo Coll, Dept Chem, Kalamazoo, MI 49006 USA
[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION | 2006年 / 34卷 / 02期
关键词：
cytochrome P450 enzyme; drug metabolism; chemical toxicity; P450; mechanism;
D O I：
10.1002/bmb.2006.49403402066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytochrome P450 (P450) enzymes include a family of related enzymes that are involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. This review presents a brief historical overview of the discovery and characterization of P450 enzymes extending from intermediary metabolism to the fields of drug metabolism and toxicology. Introductions to P450 enzyme structure and function are also presented. The goals of this review are to 1) provide an introduction to a few of the many aspects of P450 research relating to humans, 2) introduce additional ways of thinking about metabolism, 3) provide some basic examples of P450 enzymology, and 4) provide applications to topics widely taught in undergraduate courses in biochemistry.
引用
收藏
页码：66 / 74
页数：9
相关论文
共 50 条
  • [41] Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymes
    Kanayama, N.
    Kanari, C.
    Masuda, Y.
    Ohmori, S.
    Ooie, T.
    XENOBIOTICA, 2007, 37 (02) : 139 - 154
  • [42] The role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions
    Berecz, R
    Dorado, P
    De La Rubia, A
    Cáceres, MC
    Degrell, I
    LLerena, A
    CURRENT DRUG TARGETS, 2004, 5 (06) : 573 - 579
  • [43] A Multiscale Approach to Modelling Drug Metabolism by Membrane-Bound Cytochrome P450 Enzymes
    Lonsdale, Richard
    Rouse, Sarah L.
    Sansom, Mark S. P.
    Mulholland, Adrian J.
    PLOS COMPUTATIONAL BIOLOGY, 2014, 10 (07)
  • [44] The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
    Vavrova, Katarina
    Indra, Radek
    Pompach, Petr
    Heger, Zbynek
    Hodek, Petr
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
  • [45] Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo
    Turpeinen, Miia
    Uusitalo, Jouko
    Lehtinen, Terhi
    Kailajarvi, Marita
    Pelkonen, Olavi
    Vuorinen, Jouni
    Tapanainen, Pasi
    Stjernschantz, Camilla
    Lammintausta, Risto
    Scheinin, Mika
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (07): : 14064 - 14075
  • [46] Cytochrome P450 enzymes in the heart
    Seubert, J
    Yang, BC
    Bradbury, A
    Graves, J
    Miller, L
    Murphy, E
    Zeldin, DC
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 36 (05) : 772 - 772
  • [47] Engineering cytochrome P450 enzymes
    Gillam, Elizabeth M. J.
    CHEMICAL RESEARCH IN TOXICOLOGY, 2008, 21 (01) : 220 - 231
  • [48] Immobilization of cytochrome P450 enzymes onto magnetic beads: An approach to drug metabolism and biocatalysis
    Furlani, Izadora Liranco
    Oliveira, Regina Vincenzi
    Cass, Quezia Bezerra
    TALANTA OPEN, 2023, 7
  • [49] Cytochrome P450 enzymes in the vasculature
    Fleming, I
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 36 (05) : 728 - 729
  • [50] Cytochrome P450 Enzymes and the Heart
    Chaudhary, Ketul R.
    Batchu, Nagarjun
    Seubert, John M.
    IUBMB LIFE, 2009, 61 (10) : 954 - 960
12345