Cytochrome P450 enzymes in drug metabolism and chemical toxicology

被引：116
|
作者：
Furge, LL
Guengerich, FP
机构：
[1] Kalamazoo Coll, Dept Chem, Kalamazoo, MI 49006 USA
[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION | 2006年 / 34卷 / 02期
关键词：
cytochrome P450 enzyme; drug metabolism; chemical toxicity; P450; mechanism;
D O I：
10.1002/bmb.2006.49403402066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytochrome P450 (P450) enzymes include a family of related enzymes that are involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. This review presents a brief historical overview of the discovery and characterization of P450 enzymes extending from intermediary metabolism to the fields of drug metabolism and toxicology. Introductions to P450 enzyme structure and function are also presented. The goals of this review are to 1) provide an introduction to a few of the many aspects of P450 research relating to humans, 2) introduce additional ways of thinking about metabolism, 3) provide some basic examples of P450 enzymology, and 4) provide applications to topics widely taught in undergraduate courses in biochemistry.
引用
收藏
页码：66 / 74
页数：9
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