New isoflavones with cytotoxic activity from the rhizomes of Iris germanica L.

被引：24

作者：

Xie, Guo-Yong ^{[1
]}

Qin, Xiao-Ying ^{[1
]}

Liu, Rui ^{[1
]}

Wang, Qi ^{[1
]}

Lin, Bin-Bin ^{[1
]}

Wang, Guo-Kai ^{[1
]}

Xu, Guang-Kai ^{[1
]}

Wen, Rui ^{[1
]}

Qin, Min-Jian ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Resources Sci Tradit Chinese Med, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 23期

关键词：

Iridaceae; Iris germanica L; isoflavone; iriskashmirianin A; germanaism H; GLYCOSIDES;

D O I：

10.1080/14786419.2013.796468

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds, 5-methoxy-3,4-dihydroxy-6,7-methylenedioxy-4H-1-benzo-pyran-4-one(iriskashmirianin A) (1) and 5,3-dihydroxy-3-(4--d-glucopyranosyl)-6,7-methylenedioxy-4H-1-benzo-pyran-4-one (germanaism H) (2), along with eight known compounds (3-10), were isolated from the rhizomes of Iris germanica L. The cytotoxicities of these compounds were tested using Ehrlich's ascites carcinoma (EAC) cancer cell line by 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazoli-umbromide (MTT) and ATP assays. The results showed that these compounds possessed antiproliferative effects on EAC cell line. Among them, compound 1 possessed the best cytotoxic activity with IC50 +/- SD of 20.9 +/- 2.7 and 4.3 +/- 0.9M for MTT and ATP assay methods, respectively.

引用

页码：2173 / 2177

页数：5

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