New isoflavones with cytotoxic activity from the rhizomes of Iris germanica L.

被引：24
|
作者：
Xie, Guo-Yong [1 ]
Qin, Xiao-Ying [1 ]
Liu, Rui [1 ]
Wang, Qi [1 ]
Lin, Bin-Bin [1 ]
Wang, Guo-Kai [1 ]
Xu, Guang-Kai [1 ]
Wen, Rui [1 ]
Qin, Min-Jian [1 ]
机构：
[1] China Pharmaceut Univ, Dept Resources Sci Tradit Chinese Med, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 23期
关键词：
Iridaceae; Iris germanica L; isoflavone; iriskashmirianin A; germanaism H; GLYCOSIDES;
D O I：
10.1080/14786419.2013.796468
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new compounds, 5-methoxy-3,4-dihydroxy-6,7-methylenedioxy-4H-1-benzo-pyran-4-one(iriskashmirianin A) (1) and 5,3-dihydroxy-3-(4--d-glucopyranosyl)-6,7-methylenedioxy-4H-1-benzo-pyran-4-one (germanaism H) (2), along with eight known compounds (3-10), were isolated from the rhizomes of Iris germanica L. The cytotoxicities of these compounds were tested using Ehrlich's ascites carcinoma (EAC) cancer cell line by 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazoli-umbromide (MTT) and ATP assays. The results showed that these compounds possessed antiproliferative effects on EAC cell line. Among them, compound 1 possessed the best cytotoxic activity with IC50 +/- SD of 20.9 +/- 2.7 and 4.3 +/- 0.9M for MTT and ATP assay methods, respectively.
引用
收藏
页码：2173 / 2177
页数：5
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