Germline MC1R variants and BRAF mutant melanoma

被引：9
|
作者：
Hacker, Elke [1 ]
Hayward, Nicholas K. [1 ]
机构：
[1] Queensland Inst Med Res, Oncogen Lab, Brisbane, Qld 4006, Australia
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 10期
关键词：
D O I：
10.1038/jid.2008.236
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.
引用
收藏
页码：2354 / 2356
页数：4
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